Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8fhs
Q-score: 0.47
Gao S, Yao X, Chen J, Huang G, Fan X, Xue L, Li Z, Wu T, Zheng Y, Huang J, Jin X, Wang Y, Wang Z, Yu Y, Liu L, Pan X, Song C, Yan N
Cell (2023) 186 pp. 5363-5374.e16 [ DOI: doi:10.1016/j.cell.2023.10.007 Pubmed: 37972591 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Sofosbuvir (529 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit alpha-1c (249 kDa, Protein from Homo sapiens)
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
- Cav1.2 (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8we6
Q-score: 0.491
Gao S, Yao X, Chen J, Huang G, Fan X, Xue L, Li Z, Wu T, Zheng Y, Huang J, Jin X, Wang Y, Wang Z, Yu Y, Liu L, Pan X, Song C, Yan N
Cell (2023) 186 pp. 5363-5374.e16 [ Pubmed: 37972591 DOI: doi:10.1016/j.cell.2023.10.007 ]
- Voltage-dependent l-type calcium channel subunit alpha-1c (246 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cav1.2 (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Calcium ion (40 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8we7
Q-score: 0.436
Gao S, Yao X, Chen J, Huang G, Fan X, Xue L, Li Z, Wu T, Zheng Y, Huang J, Jin X, Wang Y, Wang Z, Yu Y, Liu L, Pan X, Song C, Yan N
Cell (2023) 186 pp. 5363-5374.e16 [ Pubmed: 37972591 DOI: doi:10.1016/j.cell.2023.10.007 ]
- Voltage-dependent l-type calcium channel subunit alpha-1c (246 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calciseptin (7 kDa, Protein from Dendroaspis polylepis polylepis)
- Cav1.2 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8we8
Q-score: 0.475
Gao S, Yao X, Chen J, Huang G, Fan X, Xue L, Li Z, Wu T, Zheng Y, Huang J, Jin X, Wang Y, Wang Z, Yu Y, Liu L, Pan X, Song C, Yan N
Cell (2023) 186 pp. 5363-5374.e16 [ DOI: doi:10.1016/j.cell.2023.10.007 Pubmed: 37972591 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Amlodipine (408 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit alpha-1c (246 kDa, Protein from Homo sapiens)
- Cav1.2 (Complex from Homo sapiens)
- Calciseptin (7 kDa, Protein from Dendroaspis polylepis polylepis)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8we9
Q-score: 0.47
Gao S, Yao X, Chen J, Huang G, Fan X, Xue L, Li Z, Wu T, Zheng Y, Huang J, Jin X, Wang Y, Wang Z, Yu Y, Liu L, Pan X, Song C, Yan N
Cell (2023) 186 pp. 5363-5374.e16 [ DOI: doi:10.1016/j.cell.2023.10.007 Pubmed: 37972591 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit alpha-1c (246 kDa, Protein from Homo sapiens)
- Cav1.2 (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wea
Q-score: 0.349
Gao S, Yao X, Chen J, Huang G, Fan X, Xue L, Li Z, Wu T, Zheng Y, Huang J, Jin X, Wang Y, Wang Z, Yu Y, Liu L, Pan X, Song C, Yan N
Cell (2023) 186 pp. 5363-5374.e16 [ DOI: doi:10.1016/j.cell.2023.10.007 Pubmed: 37972591 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1c (246 kDa, Protein from Homo sapiens)
- Cav1.2 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- 4-[(2-bromanyl-4,5-dimethoxy-phenyl)methyl]-4-[2-[2-[(1~{r},2~{s},5~{r})-6,6-dimethyl-2-bicyclo[3.1.1]heptanyl]ethoxy]ethyl]morpholin-4-ium (511 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8e56
Q-score: 0.54
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ Pubmed: 36417914 DOI: doi:10.1016/j.cell.2022.10.024 ]
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from rabbit)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from rabbit)
- Calcium ion (40 Da, Ligand)
- Cav1.1 (Complex from Oryctolagus cuniculus)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from rabbit)
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8e57
Q-score: 0.534
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ DOI: doi:10.1016/j.cell.2022.10.024 Pubmed: 36417914 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from rabbit)
- Propan-2-yl (2s)-2-{[(s)-{[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-4-ethynyl-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name) (535 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from rabbit)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from rabbit)
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cav1.1 (Complex from Oryctolagus cuniculus)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8e58
Q-score: 0.533
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ DOI: doi:10.1016/j.cell.2022.10.024 Pubmed: 36417914 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from rabbit)
- Propan-2-yl (2s)-2-{[(s)-{[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-4-ethynyl-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name) (535 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from rabbit)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from rabbit)
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cav1.1 (Complex from Oryctolagus cuniculus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8e59
Q-score: 0.446
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ Pubmed: 36417914 DOI: doi:10.1016/j.cell.2022.10.024 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cav1.3 (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1d (245 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)