Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ve1
Q-score: 0.607
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Transthyretin (56 kDa, Complex from Homo sapiens)
- 3-(dimethylamino)-5-[(e)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid (311 Da, Ligand)
Unliganded human transthyretin in the canonical conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve2
Q-score: 0.485
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the compressed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve3
Q-score: 0.498
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
Unliganded human transthyretin in the frayed conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ve4
Q-score: 0.477
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Transthyretin (55 kDa, Complex from Homo sapiens)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ve5
Q-score: 0.489
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (57 kDa, Complex from Homo sapiens)
- Transthyretin (15 kDa, Protein from Homo sapiens)
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
(Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8ve6
Q-score: 0.447
Basanta B, Nugroho K, Yan N, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen J, Forli S, Kelly JW, Lander GC
To Be Published
- Transthyretin (57 kDa, Complex from Homo sapiens)
- Transthyretin (15 kDa, Protein from Homo sapiens)
- 2-[(3,5-dichloro-4-trioxidanylphenyl)amino]benzoic acid (330 Da, Ligand)
EsN-dhsU36mm2 full map (map 1)
Mueller AU, Chen J, Wu M, Chiu C, Nixon BT, Campbell EA, Darst SA
PNAS (2023) 120 pp. e2220874120-e2220874120 [ DOI: doi:10.1073/pnas.2220874120 Pubmed: 36972428 ]
- Rna polymerase omega subunit (Protein from Escherichia coli)
- Rna polymerase beta subunit (Protein from Escherichia coli)
- Rna polymerase alpha subunit (Protein from Escherichia coli)
- Rna polymerase beta' subunit (Protein from Escherichia coli)
- Dhsu36mm2 bottom strand (DNA from Aquifex aeolicus)
- Sigma n / sigma 54 (Protein from Escherichia coli)
- Dhsu36mm2 top strand (DNA from Aquifex aeolicus)
- Esn-dhsu36mm2 (Complex)
EsN-dhsU36duplex full map (map 1)
Mueller AU, Chen J, Wu M, Chiu C, Nixon BT, Campbell EA, Darst SA
PNAS (2023) 120 pp. e2220874120-e2220874120 [ DOI: doi:10.1073/pnas.2220874120 Pubmed: 36972428 ]
- Rna polymerase omega subunit (Protein from Escherichia coli)
- Rna polymerase beta subunit (Protein from Escherichia coli)
- Rna polymerase alpha subunit (Protein from Escherichia coli)
- Dhsu36duplex top strand (DNA from Aquifex aeolicus)
- Esn-dhsu36duplex (Complex)
- Dhsu36duplex bottom strand (DNA from Aquifex aeolicus)
- Rna polymerase beta' subunit (Protein from Escherichia coli)
- Rna polymerase sigma-54 factor (Protein from Escherichia coli)
EsN-dhsU36mm1 full map (map 1)
Mueller AU, Chen J, Wu M, Chiu C, Nixon BT, Campbell EA, Darst SA
PNAS (2023) 120 pp. e2220874120-e2220874120 [ DOI: doi:10.1073/pnas.2220874120 Pubmed: 36972428 ]
- Sigma n / sigma 54 (Protein from Escherichia coli)
- Rna polymerase alpha subunit (Protein from Escherichia coli)
- Dhsu36mm1 top strand (DNA from Aquifex aeolicus)
- Rna polymerase omega subunit (Protein from Escherichia coli)
- Rna polymerase beta' subunit (Protein from Escherichia coli)
- Rna polymerase beta subunit (Protein from Escherichia coli)
- Dhsu36mm1 bottom strand (DNA from Aquifex aeolicus)
- Esn-dhsu36mm1 (Complex)