Electron Microscopy Data Bank

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hOCT1 in complex with metformin in outward open conformation

Release date: March 27, 2024
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 8jts
Q-score: 0.333

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)
Metformin (129 Da, Ligand)
Human organic cation transporter in compelx wtih metformin in outward open conformation (Complex from Homo sapiens)

EMD-36652

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hOCT1 in complex with metformin in outward occluded conformation

Release date: March 27, 2024
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8jtt
Q-score: 0.289

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Human organic cation transporter in compelx wtih metformin in outward occluded conformation (Complex from Homo sapiens)
Metformin (129 Da, Ligand)
Solute carrier family 22 member 1 (58 kDa, Protein from Homo sapiens)

EMD-36653

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hOCT1 in complex with metformin in inward occluded conformation

Release date: March 27, 2024
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8jtv
Q-score: 0.346

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ Pubmed: 38485705 DOI: doi:10.1038/s41421-024-00664-1 ]

Sample:

Human organic cation transporter in compelx wtih metformin in inward occludded conformation (Complex from Homo sapiens)
Metformin (129 Da, Ligand)
Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)

EMD-36654

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hOCT1 in complex with nb5660 in inward facing partially open 1 conformation

Release date: March 27, 2024
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8jtw
Q-score: 0.468

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ Pubmed: 38485705 DOI: doi:10.1038/s41421-024-00664-1 ]

Sample:

Nanobody 56 (14 kDa, Protein from Lama glama)
Human organic cation transporter in compelx wtih nb5660 in inward facing partially open 1 conformation (Complex from Homo sapiens)
Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)

EMD-36655

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hOCT1 in complex with nb5660 in inward facing fully open conformation

Release date: March 27, 2024
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8jtx
Q-score: 0.482

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ Pubmed: 38485705 DOI: doi:10.1038/s41421-024-00664-1 ]

Sample:

Nanobody 56 (14 kDa, Protein from Lama glama)
Human organic cation transporter in compelx wtih nb5660 in inward facing fully open conformation (Complex from Homo sapiens)
Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)

EMD-36658

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hOCT1 in complex with spironolactone in inward facing occluded conformation

Release date: March 27, 2024
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8ju0
Q-score: 0.503

Zhang S, Zhu A, Kong F, Chen J, Lan B, He G, Gao K, Cheng L, Sun X, Yan C, Chen L, Liu X

Cell Discov (2024) 10 pp. 30-30 [ DOI: doi:10.1038/s41421-024-00664-1 Pubmed: 38485705 ]

Sample:

Spironolactone (416 Da, Ligand)
Human organic cation transporter in compelx wtih spironolactone in inward facing occludded conformation (Complex from Homo sapiens)
Solute carrier family 22 member 1 (62 kDa, Protein from Homo sapiens)

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