Bovine multidrug resistance protein 1 (MRP1) bound to cyclic peptide inhibitor 1 (CPI1)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8f4b
Q-score: 0.46
Pietz HL, Abbas A, Johnson ZL, Oldham ML, Suga H, Chen J
PNAS (2023) 120 pp. e2220012120-e2220012120 [ DOI: doi:10.1073/pnas.2220012120 Pubmed: 36893260 ]
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7f16
Q-score: 0.415
Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2101279118 Pubmed: 34353904 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Tuberoinfundibular peptide of 39 residues (4 kDa, Protein from Homo sapiens)
- Parathyroid hormone 2 receptor (49 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Lama glama)
PA28alpha-beta in complex with immunoproteasome
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7dr6
Q-score: 0.24
Chen J, Wang Y, Xu C, Chen K, Zhao Q, Wang S, Yin Y, Peng C, Ding Z, Cong Y
Nat Commun (2021) 12 pp. 739-739 [ Pubmed: 33531497 DOI: doi:10.1038/s41467-021-21028-3 ]
- Proteasome subunit alpha type-1 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-8 (30 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Bos taurus)
- Proteasome activator complex subunit 2 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Bos taurus)
- Proteasome activator complex subunit 1 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-10 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-9 (23 kDa, Protein from Bos taurus)
- 20s proteasome purified from bovine spleen in complex of human pa28 (Complex from Bos taurus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-3 (23 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Bos taurus)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7dr7
Q-score: 0.448
Chen J, Wang Y, Xu C, Chen K, Zhao Q, Wang S, Yin Y, Peng C, Ding Z, Cong Y
Nat Commun (2021) 12 pp. 739-739 [ Pubmed: 33531497 DOI: doi:10.1038/s41467-021-21028-3 ]
- Proteasome subunit alpha type-5 (26 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-9 (23 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Bos taurus)
- 20s immunoproteasome purified from bovine spleen (Complex from Bos taurus)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-3 (23 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-10 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-8 (30 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Bos taurus)
Bovine 20S immunoproteasome in complex with two human PA28alpha-beta activators
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7drw
Q-score: 0.179
Chen J, Wang Y, Xu C, Chen K, Zhao Q, Wang S, Yin Y, Peng C, Ding Z, Cong Y
Nat Commun (2021) 12 pp. 739-739 [ Pubmed: 33531497 DOI: doi:10.1038/s41467-021-21028-3 ]
- Proteasome subunit alpha type-5 (26 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-9 (23 kDa, Protein from Bos taurus)
- Proteasome activator complex subunit 1 (28 kDa, Protein from Homo sapiens)
- Proteasome activator complex subunit 2 (27 kDa, Protein from Homo sapiens)
- 20s immunoproteasome purified from bovine spleen (Complex from Bos taurus)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-3 (23 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-10 (29 kDa, Protein from Bos taurus)
- Proteasome subunit beta type-8 (30 kDa, Protein from Bos taurus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Bos taurus)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 6uy0
Q-score: 0.515
Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S
eLife (2020) 9 [ Pubmed: 32458799 DOI: doi:10.7554/eLife.56451 ]
- Multidrug resistance-associated protein 1 (172 kDa, Protein from Bos taurus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Bovine multidrug resistance protein 1 (mrp1) (170 kDa, Complex from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6nbf
Q-score: 0.444
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y
Science (2019) 364 pp. 148-153 [ DOI: doi:10.1126/science.aav7942 Pubmed: 30975883 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Palmitic acid (256 Da, Ligand)
- Long-acting parathyroid hormone analog (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Gs protein alpha subunit (43 kDa, Protein from Bos taurus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Cryo-em structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and g protein (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6nbh
Q-score: 0.347
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y
Science (2019) 364 pp. 148-153 [ DOI: doi:10.1126/science.aav7942 Pubmed: 30975883 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Palmitic acid (256 Da, Ligand)
- Long-acting parathyroid hormone analog (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Gs protein alpha subunit (43 kDa, Protein from Bos taurus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Cryo-em structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and g protein (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6nbi
Q-score: 0.285
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y
Science (2019) 364 pp. 148-153 [ DOI: doi:10.1126/science.aav7942 Pubmed: 30975883 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Long-acting parathyroid hormone analog (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Gs protein alpha subunit (43 kDa, Protein from Bos taurus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Cryo-em structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and g protein (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 6bhu
Q-score: 0.461
Cell (2018) 172 pp. 81-89.e10 [ Pubmed: 29290467 DOI: doi:10.1016/j.cell.2017.12.005 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Multidrug resistance-associated protein 1 (183 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Bovine multidrug resistance protein 1 (mrp1) e1454q (170 kDa, Complex from Bos taurus)