Pre-fusion Measles virus fusion protein complexed with Fab 77
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8ut2
Q-score: 0.583
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Saphire EO
Science (2024) [ DOI: doi:10.1126/science.adm8693 ]
- Mab 77 light chain (25 kDa, Protein from Mus musculus)
- Mab 77 heavy chain (52 kDa, Protein from Mus musculus)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles morbillivirus)
- Water (18 Da, Ligand)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles morbillivirus)
- Antibody 77 fab heavy chain, antibody 77 fab light chain (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of measles fusion glycoprotein in complex with fab 77 (Complex)
- Measles virus fusion glycoprotein (Complex from Measles morbillivirus)
Structure of the Measles virus Fusion protein in the post-fusion conformation
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8utf
Q-score: 0.572
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Saphire EO
Science (2024) [ DOI: doi:10.1126/science.adm8693 ]
- Fusion glycoprotein f0 (12 kDa, Protein from Measles morbillivirus)
- Water (18 Da, Ligand)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles morbillivirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of the measles virus fusion protein in the post-fusion conformation (Complex from Measles morbillivirus)
Structure of the Measles virus Fusion protein in the pre-fusion conformation
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 8uup
Q-score: 0.637
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Saphire EO
Science (2024) [ DOI: doi:10.1126/science.adm8693 ]
- Fusion glycoprotein f0 (12 kDa, Protein from Measles morbillivirus)
- Water (18 Da, Ligand)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles morbillivirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of the measles virus fusion protein in the pre-fusion conformation (Complex from Measles morbillivirus)
Resolution: 2.34 Å
EM Method: Single-particle
Fitted PDBs: 8uuq
Q-score: 0.663
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Saphire EO
Science (2024) [ DOI: doi:10.1126/science.adm8693 ]
- Fusion glycoprotein f0 (12 kDa, Protein from Measles morbillivirus)
- [fip-hrc]2-peg11 (503 Da, Protein from synthetic construct)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles morbillivirus)
- Water (18 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of the measles virus fusion protein in the pre-fusion conformation with bound [fip-hrc]2-peg11 (Complex from Measles morbillivirus)
Fab 77-stabilized MeV F ectodomain fragment
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9at8
Q-score: 0.444
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Saphire EO
Science (2024) [ DOI: doi:10.1126/science.adm8693 ]
- Antibody 77 fab heavy chain, antibody 77 fab light chain (Complex from Mus musculus)
- Mab 77 heavy chain (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Measles virus fusion glycoprotein (Complex from Measles morbillivirus)
- Mab 77 light chain (25 kDa, Protein from Homo sapiens)
- Fusion glycoprotein f0 (57 kDa, Protein from Measles morbillivirus)
- Fab 77-stabilized mev f ectodomain fragment (43 kDa, Complex)
Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody M28
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8dmh
Q-score: 0.515
Moon-Walker A, Zhang Z, Zyla DS, Buck TK, Li H, Diaz Avalos R, Schendel SL, Hastie KM, Crotty S, Saphire EO
Cell Chem Biol (2023) 30 pp. 403-411.e4 [ Pubmed: 36990092 DOI: doi:10.1016/j.chembiol.2023.03.005 ]
- Glycoprotein (Complex from Lymphocytic choriomeningitis mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody m28 (Complex)
- 18.5c-m28 fab light chain (23 kDa, Protein from Homo sapiens)
- 18.5c-m28 fab light chain, 18.5c-m28 fab heavy chain (Complex from Homo sapiens)
- Glycoprotein g1 (25 kDa, Protein from Lymphocytic choriomeningitis virus)
- Glycoprotein g2,cobalamin adenosyltransferase-like domain-containing protein trimerization tag (42 kDa, Protein from Lymphocytic choriomeningitis virus)
- 18.5c-m28 fab heavy chain (23 kDa, Protein from Homo sapiens)
Lymphocytic choriomeningitis virus glycoprotein
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8dmi
Q-score: 0.454
Moon-Walker A, Zhang Z, Zyla DS, Buck TK, Li H, Diaz Avalos R, Schendel SL, Hastie KM, Crotty S, Saphire EO
Cell Chem Biol (2023) 30 pp. 403-411.e4 [ DOI: doi:10.1016/j.chembiol.2023.03.005 Pubmed: 36990092 ]
- Lymphocytic choriomeningitis virus glycoprotein (Complex from Lymphocytic choriomeningitis mammarenavirus)
- Glycoprotein g2,cobalamin adenosyltransferase-like domain-containing protein trimerization tag (42 kDa, Protein from Lymphocytic choriomeningitis virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein g1 (25 kDa, Protein from Lymphocytic choriomeningitis virus)
Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7uot
Q-score: 0.559
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ DOI: doi:10.1126/scitranslmed.abq0991 Pubmed: 36288283 ]
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- Native lassa glycoprotein in complex with 8.9f-scfv and 37.2d-scfv (Complex)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- 8.9f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 8.9f heavy chain (variable domain) (15 kDa, Protein from Homo sapiens)
Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7uov
Q-score: 0.541
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ DOI: doi:10.1126/scitranslmed.abq0991 Pubmed: 36288283 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Native lassa glycoprotein in complex with 12.1f-scfv and 37.2d-scfv (Complex)
- 12.1f heavy chain (variable domain) (12 kDa, Protein from Homo sapiens)
- 12.1f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)