Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 5umd
Q-score: 0.46
Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SH, Baum J
Nat Microbiol (2017) 2 pp. 17031-17031 [ Pubmed: 28288098 DOI: doi:10.1038/nmicrobiol.2017.31 ]
- 60s ribosomal protein l28 (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l39 (6 kDa, Protein from Plasmodium falciparum 3D7)
- 5.8s ribosomal rna (51 kDa, RNA from Plasmodium falciparum 3D7)
- 60s ribosomal protein l26, putative (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l35ae, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l37a (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l35, putative (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l31 (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l13 (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l11a, putative (20 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l18a (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l6-2, putative (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l22, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l7, putative (30 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l41 (5 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l7-3, putative (32 kDa, Protein from Plasmodium falciparum 3D7)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l19 (21 kDa, Protein from Plasmodium falciparum 3D7)
- Ribosomal protein l37 (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l21 (18 kDa, Protein from Plasmodium falciparum 3D7)
- Mefloquine (378 Da, Ligand)
- 60s ribosomal protein l3 (44 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l6, putative (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l13, putative (23 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l34 (17 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l36 (12 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l4 (46 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l27a, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l10, putative (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l27 (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l29, putative (8 kDa, Protein from Plasmodium falciparum 3D7)
- Ribosomal protein l15 (24 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l18-2, putative (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l44 (12 kDa, Protein from Plasmodium falciparum 3D7)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l2 (28 kDa, Protein from Plasmodium falciparum 3D7)
- 28s ribosomal rna (1 MDa, RNA from Plasmodium falciparum 3D7)
- 60s ribosomal protein l5, putative (34 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l38 (10 kDa, Protein from Plasmodium falciparum 3D7)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l14, putative (19 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l17, putative (23 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l32 (15 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l23, putative (15 kDa, Protein from Plasmodium falciparum 3D7)
- 5s ribosomal rna (38 kDa, RNA from Plasmodium falciparum 3D7)
- 60s ribosomal protein l30e, putative (11 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l24, putative (19 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 80s ribosome bound to mefloquine (4 MDa, Complex from Plasmodium falciparum 3D7)
- 60s ribosomal protein l23 (22 kDa, Protein from Plasmodium falciparum 3D7)