Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8twe
Q-score: 0.592
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ Pubmed: 38123684 DOI: doi:10.1038/s41586-023-06870-3 ]
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Ppp2r1a-ppp2r2a-interacting phosphatase regulator 1 (10 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 55 kda regulatory subunit b alpha isoform (52 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to fam122a (Complex)
Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8twi
Q-score: 0.499
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ Pubmed: 38123684 DOI: doi:10.1038/s41586-023-06870-3 ]
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Ppp2r1a-ppp2r2a-interacting phosphatase regulator 1 (10 kDa, Protein from Homo sapiens)
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to fam122a (Complex)
- Fe (iii) ion (55 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of the PP2A:B55-FAM122A complex
Resolution: 2.79961 Å
EM Method: Single-particle
Fitted PDBs: 8so0
Q-score: 0.561
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ Pubmed: 38123684 DOI: doi:10.1038/s41586-023-06870-3 ]
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Ppp2r1a-ppp2r2a-interacting phosphatase regulator 1 (10 kDa, Protein from Homo sapiens)
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to fam122a (Complex)
- Fe (iii) ion (55 Da, Ligand)
- Serine/threonine-protein phosphatase 2a 55 kda regulatory subunit b alpha isoform (52 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of the PP2A:B55-ARPP19 complex
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8ttb
Q-score: 0.564
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ Pubmed: 38123684 DOI: doi:10.1038/s41586-023-06870-3 ]
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Camp-regulated phosphoprotein 19 (12 kDa, Protein from Homo sapiens)
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to thiophosphorylated arpp19 (165 kDa, Complex)
- Zinc ion (65 Da, Ligand)
- Serine/threonine-protein phosphatase 2a 55 kda regulatory subunit b alpha isoform (52 kDa, Protein from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
Cryo EM structure of Vibrio cholerae NQR
Resolution: 2.5804 Å
EM Method: Single-particle
Fitted PDBs: 8evu
Q-score: 0.591
To Be Published
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae O395)
- Flavin mononucleotide (456 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase (Complex from Vibrio cholerae O395)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae O395)
- Ubiquinone-1 (250 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae O395)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit a (48 kDa, Protein from Vibrio cholerae O395)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae O395)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae O395)
- Riboflavin (376 Da, Ligand)
Cryo EM structure of Vibrio cholerae NQR
Resolution: 2.65159 Å
EM Method: Single-particle
Fitted PDBs: 8ew3
Q-score: 0.565
To Be Published
- Flavin mononucleotide (456 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae O395)
- Na(+)-translocating nadh-quinone reductase (Complex from Vibrio cholerae O395)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae O395)
- Ubiquinone-1 (250 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae O395)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit a (48 kDa, Protein from Vibrio cholerae O395)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae O395)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae O395)
- Riboflavin (376 Da, Ligand)
Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7upi
Q-score: 0.527
Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ
Nature (2022) 609 pp. 408-415 [ Pubmed: 35831509 DOI: doi:10.1038/s41586-022-04928-2 ]
- Chloride ion (35 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- Ras-related protein m-ras (20 kDa, Protein from Homo sapiens)
- Leucine-rich repeat protein shoc-2 (65 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Shoc2-pp1c-mras holophosphatase (Complex from Homo sapiens)
- Serine/threonine-protein phosphatase pp1-alpha catalytic subunit (37 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7kwo
Q-score: 0.462
Fuller JR, Knockenhauer KE, Leksa NC, Peters RT, Batchelor JD
Blood (2021) 137 pp. 2970-2980 [ DOI: doi:10.1182/blood.2020009197 Pubmed: 33569592 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Copper (ii) ion (63 Da, Ligand)
- Rfviiifc-vwf-xten (bivv001) (311 kDa, Complex from Homo sapiens)
- Coagulation factor fviii-fc-xten (218 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Von willebrand factor-xten-fc (179 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
McGilvray PT, Anghel SA, Sundaram A, Zhong F, Trnka MJ, Fuller JR, Hu H, Burlingame AL, Keenan RJ
eLife (2020) 9 [ DOI: doi:10.7554/eLife.56889 Pubmed: 32820719 ]
- Sec61 complex (Complex from Homo sapiens)
- Nomo (Complex from Homo sapiens)
- Sec61 gamma (Complex from Homo sapiens)
- Translocon (Complex)
- Tmem147 (Complex from Homo sapiens)
- Nicalin (Complex from Homo sapiens)
- Sec61 alpha (Complex from Homo sapiens)
- Sec61 beta (Complex from Homo sapiens)
- Tmco1 (Complex from Homo sapiens)
- Native complex of a translating ribosome and a novel translocon containing the sec61 complex, tmem147, nomo, nicalin, ccdc47, and tmco1 (140 kDa, Complex from Homo sapiens)
- Ccdc47 (Complex from Homo sapiens)
- Nomo-nicalin-tmem147 complex (Complex from Homo sapiens)
McGilvray PT, Anghel SA, Sundaram A, Zhong F, Trnka MJ, Fuller JR, Hu H, Burlingame AL, Keenan RJ
eLife (2020) 9 [ Pubmed: 32820719 DOI: doi:10.7554/eLife.56889 ]
- 60s ribosomal protein l18a (Complex from Homo sapiens)
- 40s ribosomal protein s28 (Complex from Homo sapiens)
- 40s ribosomal protein s30 (Complex from Homo sapiens)
- 60s ribosomal protein l7 (Complex from Homo sapiens)
- 40s ribosomal protein s26 (Complex from Homo sapiens)
- 40s ribosomal protein s21 (Complex from Homo sapiens)
- 60s ribosomal protein l24 (Complex from Homo sapiens)
- 40s ribosomal protein s16 (Complex from Homo sapiens)
- 40s ribosomal protein s9 (Complex from Homo sapiens)
- 60s ribosomal protein l18 (Complex from Homo sapiens)
- 40s ribosomal protein s4, x isoform (Complex from Homo sapiens)
- 40s ribosomal protein s10 (Complex from Homo sapiens)
- 60s ribosomal protein l10a (Complex from Homo sapiens)
- 40s ribosomal protein s18 (Complex from Homo sapiens)
- 60s ribosomal protein l17 (Complex from Homo sapiens)
- 40s ribosomal protein s23 (Complex from Homo sapiens)
- 40s ribosomal protein s25 (Complex from Homo sapiens)
- 60s ribosomal protein l11 (Complex from Homo sapiens)
- 60s ribosomal protein l3 (Complex from Homo sapiens)
- 40s ribosomal protein s7 (Complex from Homo sapiens)
- Nomo-nicalin-tmem147 complex (Complex from Homo sapiens)
- 60s ribosomal protein l27a (Complex from Homo sapiens)
- Translocon (Complex from Homo sapiens)
- 40s ribosomal protein s6 (Complex from Homo sapiens)
- 60s ribosomal protein l9 (Complex from Homo sapiens)
- 40s ribosomal protein s14 (Complex from Homo sapiens)
- 40s ribosomal protein s5 (Complex from Homo sapiens)
- 40s ribosomal protein s12 (Complex from Homo sapiens)
- 60s ribosomal protein l30 (Complex from Homo sapiens)
- 60s ribosomal protein l14 (Complex from Homo sapiens)
- 60s ribosomal protein l23 (Complex from Homo sapiens)
- 60s ribosomal protein l23a (Complex from Homo sapiens)
- 60s ribosomal protein l36a (Complex from Homo sapiens)
- 40s ribosomal protein s15a (Complex from Homo sapiens)
- 60s ribosomal protein l27 (Complex from Homo sapiens)
- 40s subunit (1 MDa, Complex from Homo sapiens)
- 60s acidic ribosomal protein p1 (Complex from Homo sapiens)
- 60s ribosomal protein l22 (Complex from Homo sapiens)
- 60s ribosomal protein l31 (Complex from Homo sapiens)
- 40s ribosomal protein s3a (Complex from Homo sapiens)
- 60s ribosomal protein l19 (Complex from Homo sapiens)
- 40s ribosomal protein s24 (Complex from Homo sapiens)
- 60s subunit (2 MDa, Complex from Homo sapiens)
- 40s ribosomal protein s2 (Complex from Homo sapiens)
- Ccdc47 (Complex from Homo sapiens)
- 60s ribosomal protein l7a (Complex from Homo sapiens)
- 60s ribosomal protein l6 (Complex from Homo sapiens)
- 60s ribosomal protein l34 (Complex from Homo sapiens)
- 60s ribosomal protein l35 (Complex from Homo sapiens)
- 40s ribosomal protein sa (Complex from Homo sapiens)
- 60s ribosomal protein l10 (Complex from Homo sapiens)
- 40s ribosomal protein s15 (Complex from Homo sapiens)
- 60s acidic ribosomal protein p0 (Complex from Homo sapiens)
- 60s ribosomal protein l5 (Complex from Homo sapiens)
- 60s ribosomal protein l38 (Complex from Homo sapiens)
- 60s ribosomal protein l28 (Complex from Homo sapiens)
- 60s acidic ribosomal protein p2 (Complex from Homo sapiens)
- 40s ribosomal protein s3 (Complex from Homo sapiens)
- 40s ribosomal protein s8 (Complex from Homo sapiens)
- 60s ribosomal protein l8 (Complex from Homo sapiens)
- 40s ribosomal protein s29 (Complex from Homo sapiens)
- 60s ribosomal protein l32 (Complex from Homo sapiens)
- Sec61 complex (70 kDa, Complex from Homo sapiens)
- Native complex of a translating ribosome and a novel translocon containing the sec61 complex, tmem147, nomo, nicalin, ccdc47, and tmco1. (56 kDa, Complex from Homo sapiens)
- 60s ribosomal protein l13a (Complex from Homo sapiens)
- 60s ribosomal protein l12 (Complex from Homo sapiens)
- 60s ribosomal protein l39 (Complex from Homo sapiens)
- 60s ribosomal protein l15 (Complex from Homo sapiens)
- 40s ribosomal protein s19 (Complex from Homo sapiens)
- 40s ribosomal protein s13 (Complex from Homo sapiens)
- 60s ribosomal protein l21 (Complex from Homo sapiens)
- 60s ribosomal protein l35a (Complex from Homo sapiens)
- 60s ribosomal protein l36 (Complex from Homo sapiens)
- 60s ribosomal protein l26 (Complex from Homo sapiens)
- 40s ribosomal protein s27 (Complex from Homo sapiens)
- 40s ribosomal protein s17 (Complex from Homo sapiens)
- 40s ribosomal protein s27-like (Complex from Homo sapiens)
- Tmco1 (Complex from Homo sapiens)
- 40s ribosomal protein s11 (Complex from Homo sapiens)
- 60s ribosomal protein l4 (Complex from Homo sapiens)
- 60s ribosomal protein l37a (Complex from Homo sapiens)
- 60s ribosomal protein l13 (Complex from Homo sapiens)