SARS-CoV-2 Spike bound to Fab PDI 210
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH
Cell Rep (2021) 37 pp. 109822-109822 [ Pubmed: 34610292 DOI: doi:10.1016/j.celrep.2021.109822 ]
SARS-CoV-2 Spike bound to Fab PDI 96
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH
Cell Rep (2021) 37 pp. 109822-109822 [ Pubmed: 34610292 DOI: doi:10.1016/j.celrep.2021.109822 ]
SARS-CoV-2 Spike bound to Fab PDI 215
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH
Cell Rep (2021) 37 pp. 109822-109822 [ Pubmed: 34610292 DOI: doi:10.1016/j.celrep.2021.109822 ]
SARS-CoV-2 Spike bound to Fab WCSL 119
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH
Cell Rep (2021) 37 pp. 109822-109822 [ Pubmed: 34610292 DOI: doi:10.1016/j.celrep.2021.109822 ]
SARS-CoV-2 Spike bound to Fab WCSL 129
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH
Cell Rep (2021) 37 pp. 109822-109822 [ Pubmed: 34610292 DOI: doi:10.1016/j.celrep.2021.109822 ]
SARS-CoV-2 Spike bound to Fab PDI 93
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH
Cell Rep (2021) 37 pp. 109822-109822 [ Pubmed: 34610292 DOI: doi:10.1016/j.celrep.2021.109822 ]
SARS-CoV-2 Spike bound to Fab PDI 222
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH
Cell Rep (2021) 37 pp. 109822-109822 [ Pubmed: 34610292 DOI: doi:10.1016/j.celrep.2021.109822 ]
SARS-CoV-2 receptor binding domain bound to Fab PDI 222
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 7rr0
Q-score: 0.477
Wheatley AK, Pymm P, Esterbauer R, Dietrich MH, Lee WS, Drew D, Kelly HG, Chan LJ, Mordant FL, Black KA, Adair A, Tan HX, Juno JA, Wragg KM, Amarasena T, Lopez E, Selva KJ, Haycroft ER, Cooney JP, Venugopal H, Tan LL, O Neill MT, Allison CC, Cromer D, Davenport MP, Bowen RA, Chung AW, Pellegrini M, Liddament MT, Glukhova A, Subbarao K, Kent SJ, Tham WH
Cell Rep (2021) 37 pp. 109822-109822 [ Pubmed: 34610292 DOI: doi:10.1016/j.celrep.2021.109822 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 receptor binding domain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 receptor binding domain- fab pdi 222 complex (47 kDa, Complex)
- Pdi 222 fab light chain (11 kDa, Protein from Homo sapiens)
- Fab pdi 222 (Complex from Homo sapiens)
- Pdi 222 fab heavy chain (13 kDa, Protein from Homo sapiens)
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 7lx5
Q-score: 0.478
Pymm P, Adair A, Chan LJ, Cooney JP, Mordant FL, Allison CC, Lopez E, Haycroft ER, O'Neill MT, Tan LL, Dietrich MH, Drew D, Doerflinger M, Dengler MA, Scott NE, Wheatley AK, Gherardin NA, Venugopal H, Cromer D, Davenport MP, Pickering R, Godfrey DI, Purcell DFJ, Kent SJ, Chung AW, Subbarao K, Pellegrini M, Glukhova A, Tham WH
PNAS (2021) 118 [ Pubmed: 33893175 DOI: doi:10.1073/pnas.2101918118 ]
- Sars-cov-2 spike protein receptor binding domain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Wnb 2 (14 kDa, Protein from Vicugna pacos)
- Neutralizing nanobodies wnb 2 and wnb 10 (Complex from Vicugna pacos)
- Wnb 10 (13 kDa, Protein from Vicugna pacos)
- Spike glycoprotein (152 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Focused refinement of the sars-cov-2 spike protein receptor binding domain bound to neutralizing nanobodies wnb 2 and wnb 10 (Complex)
Pymm P, Adair A, Chan LJ, Cooney JP, Mordant FL, Allison CC, Lopez E, Haycroft ER, O'Neill MT, Tan LL, Dietrich MH, Drew D, Doerflinger M, Dengler MA, Scott NE, Wheatley AK, Gherardin NA, Venugopal H, Cromer D, Davenport MP, Pickering R, Godfrey DI, Purcell DFJ, Kent SJ, Chung AW, Subbarao K, Pellegrini M, Glukhova A, Tham WH
PNAS (2021) 118 [ Pubmed: 33893175 DOI: doi:10.1073/pnas.2101918118 ]
- Wnb2 (Protein from Vicugna pacos)
- Neutralising nanobodies wnb2 and wnb10 (Complex from Vicugna pacos)
- Sars-cov-2 spike protein (Complex from evere acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em map of sars-cov-2 spike protein bound to neutralising nanobodies wnb2 and wnb10 (c3 symmetry) (Complex)
- Wnb10 (Protein from Vicugna pacos)