Structure of HIV-1 reverse transcriptase initiation complex core
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7kjv
Q-score: 0.564
Ha B, Larsen KP, Zhang J, Fu Z, Montabana E, Jackson LN, Chen DH, Puglisi EV
Nat Commun (2021) 12 pp. 2500-2500 [ DOI: doi:10.1038/s41467-021-22628-9 Pubmed: 33947853 ]
- Magnesium ion (24 Da, Ligand)
- Trna lysine 3 fragment with gnra tetraloop (12 kDa, Macromolecule from Homo sapiens)
- Hiv-1 reverse transcriptase initiation complex core (138 kDa, Complex from Human immunodeficiency virus 1)
- Hiv-1 viral rna fragment (8 kDa, RNA from Human immunodeficiency virus 1)
- Octyl beta-d-glucopyranoside (292 Da, Ligand)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 group M subtype B (isolate BH10))
- Reverse transcriptase p51 subunit (51 kDa, Protein from Human immunodeficiency virus 1)
Structure of HIV-1 reverse transcriptase initiation complex core with efavirenz
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7kjw
Q-score: 0.55
Ha B, Larsen KP, Zhang J, Fu Z, Montabana E, Jackson LN, Chen DH, Puglisi EV
Nat Commun (2021) 12 pp. 2500-2500 [ DOI: doi:10.1038/s41467-021-22628-9 Pubmed: 33947853 ]
- Reverse transcriptase p51 subunit (51 kDa, Protein from Human immunodeficiency virus 1)
- Trna lysine 3 fragment with gnra tetraloop (12 kDa, Macromolecule from Homo sapiens)
- (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one (315 Da, Ligand)
- Hiv-1 reverse transcriptase initiation complex core with efavirenz (138 kDa, Complex from Human immunodeficiency virus 1)
- Magnesium ion (24 Da, Ligand)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 group M subtype B (isolate BH10))
- Hiv-1 viral rna fragment (8 kDa, RNA from Human immunodeficiency virus 1)
Structure of HIV-1 reverse transcriptase initiation complex core with nevirapine
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7kjx
Q-score: 0.515
Ha B, Larsen KP, Zhang J, Fu Z, Montabana E, Jackson LN, Chen DH, Puglisi EV
Nat Commun (2021) 12 pp. 2500-2500 [ Pubmed: 33947853 DOI: doi:10.1038/s41467-021-22628-9 ]
- Reverse transcriptase p51 subunit (51 kDa, Protein from Human immunodeficiency virus 1)
- Magnesium ion (24 Da, Ligand)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 group M subtype B (isolate BH10))
- Hiv-1 reverse transcriptase initiation complex core with nevirapine (138 kDa, Complex from Human immunodeficiency virus 1)
- Trna lysine 3 fragment with gnra tetraloop (7 kDa, Macromolecule from Homo sapiens)
- 11-cyclopropyl-5,11-dihydro-4-methyl-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (266 Da, Ligand)
- Hiv-1 viral rna fragment (8 kDa, RNA from Human immunodeficiency virus 1)