Human spliceosomal PM5 C* complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8c6j
Q-score: 0.353
Dybkov O, Preussner M, El Ayoubi L, Feng VY, Harnisch C, Merz K, Leupold P, Yudichev P, Agafonov DE, Will CL, Girard C, Dienemann C, Urlaub H, Kastner B, Heyd F, Luehrmann R
Sci Adv (2023) 9 pp. eadf1785- [ DOI: doi:10.1126/sciadv.adf1785 Pubmed: 36867703 ]
- Peptidyl-prolyl cis-trans isomerase-like 3 (18 kDa, Protein from human)
- U5 snrna (36 kDa, RNA from human)
- Crooked neck-like protein 1 (83 kDa, Protein from human)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
- Rna-binding protein 8a (19 kDa, Protein from human)
- Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from human)
- Pre-mrna-processing factor 17 (65 kDa, Protein from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Intron-binding protein aquarius (171 kDa, Protein from human)
- Pre-mrna-processing factor 19 (55 kDa, Protein from human)
- Protein mago nashi homolog (17 kDa, Protein from human)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
- Inositol hexakisphosphate (660 Da, Ligand)
- U6 snrna (34 kDa, RNA from human)
- U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from human)
- Nitric oxide synthase-interacting protein (33 kDa, Protein from human)
- Pm5 5' exon (78 kDa, RNA from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
- Pleiotropic regulator 1 (57 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
- U2 snrna (60 kDa, RNA from human)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
- Potassium ion (39 Da, Ligand)
- Pre-mrna-splicing factor cwc22 homolog (57 kDa, Protein from human)
- Zinc ion (65 Da, Ligand)
- Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
- Splicing factor cactin (88 kDa, Protein from human)
- Splicing regulator sde2 (49 kDa, Protein from human)
- Pre-mrna-splicing factor slu7 (68 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
- Cell division cycle 5-like protein (92 kDa, Protein from human)
- Prkr-interacting protein 1 (21 kDa, Protein from human)
- Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Human spliceosomal c* complex assembled on pm5 pre-mrna (Complex from Homo sapiens)
- Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
- Sting er exit protein (25 kDa, Protein from human)
- Protein fam32a (13 kDa, Protein from human)
- Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
- Probable atp-dependent rna helicase ddx41 (69 kDa, Protein from human)
- Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
- 116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
- Snw domain-containing protein 1 (61 kDa, Protein from human)
- Protein bud31 homolog (17 kDa, Protein from human)
- Nf-kappa-b-activating protein (47 kDa, Protein from human)
- Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
- Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
- Splicing factor c9orf78 (33 kDa, Protein from human)
- Protein fam50a (40 kDa, Protein from human)
- Pm5 intron (74 kDa, RNA from Homo sapiens)
- Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
- Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
- Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
- Splicing factor ess-2 homolog (52 kDa, Protein from human)