Structure of CUL9-RBX1 ubiquitin E3 ligase complex - hexameric assembly
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 8q7e
Q-score: 0.301
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01257-y Pubmed: 38605244 ]
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Cullin-9 (281 kDa, Protein from Homo sapiens)
- Structure of cul9-rbx1 ubiquitin e3 ligase complex - hexameric assembly (Complex from Homo sapiens)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8q7h
Q-score: 0.39
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01257-y Pubmed: 38605244 ]
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Structure of cul9-rbx1 ubiquitin e3 ligase complex in unneddylated and neddylated conformation - focused cullin dimer (Complex from Homo sapiens)
- Unknown (12 kDa, Protein from Homo sapiens)
- Cullin-9 (281 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Nedd8 (9 kDa, Protein from Homo sapiens)
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01257-y Pubmed: 38605244 ]
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01257-y Pubmed: 38605244 ]
Structure of the hexameric CUL9-RBX1 complex with deletion of CUL9 CPH domain
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01257-y Pubmed: 38605244 ]
Structure of the hexameric CUL9-RBX1 complex with deletion of CUL9 DOC domain
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01257-y Pubmed: 38605244 ]
Structure of the hexameric CUL9-RBX1 complex with deletion of CUL9 ARM9 domain
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01257-y Pubmed: 38605244 ]
Structure of the hexameric CUL9-RBX1 complex with deletion of CUL9 ARIH-RBR element
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01257-y Pubmed: 38605244 ]
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8rhz
Q-score: 0.425
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01257-y Pubmed: 38605244 ]
- Structure of cul9-rbx1 ubiquitin e3 ligase complex in unneddylated conformation - symmetry expanded unneddylated dimer (Complex from Homo sapiens)
- Cullin-9 (281 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
Structure of Dimeric HECT E3 Ubiquitin Ligase UBR5
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8c06
Q-score: 0.478
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Perez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA
Nat Chem Biol (2024) 20 pp. 190-200 [ Pubmed: 37620400 DOI: doi:10.1038/s41589-023-01414-2 ]
- Dimeric hect e3 ubiquitin ligase ubr5 (620 kDa, Complex from Homo sapiens)
- E3 ubiquitin-protein ligase ubr5 (310 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)