Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Jain R" AND author_orcid:"0000-0002-8594-1074"

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EMD-26475

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Cryo-EM structure of PAPP-A in complex with IGFBP5

Release date: Sept. 28, 2022
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7ufg
Q-score: 0.443

Judge RA, Sridar J, Tunyasunvunakool K, Jain R, Wang JCK, Ouch C, Xu J, Mafi A, Nile AH, Remarcik C, Smith CL, Ghosh C, Xu C, Stoll V, Jumper J, Singh AH, Eaton D, Hao Q

Nat Commun (2022) 13 pp. 5500- [ Pubmed: 36127359 DOI: doi:10.1038/s41467-022-33175-2 ]

Sample:

Zinc ion (65 Da, Ligand)
Complex of papp-a with igfbp5 (Complex from Homo sapiens)
Pappalysin-1 (176 kDa, Protein from Homo sapiens)
Insulin-like growth factor-binding protein 5 (30 kDa, Protein from Homo sapiens)

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EMD-27253

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Cryo-EM structure of substrate unbound PAPP-A

Release date: Sept. 28, 2022
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8d8o
Q-score: 0.44

Judge RA, Sridar J, Tunyasunvunakool K, Jain R, Wang JCK, Ouch C, Xu J, Mafi A, Nile AH, Remarcik C, Smith CL, Ghosh C, Xu C, Stoll V, Jumper J, Singh AH, Eaton D, Hao Q

Nat Commun (2022) 13 pp. 5500- [ Pubmed: 36127359 DOI: doi:10.1038/s41467-022-33175-2 ]

Sample:

Papp-a homodimer (Complex from Homo sapiens)
Zinc ion (65 Da, Ligand)
Pappalysin-1 (176 kDa, Protein from Homo sapiens)

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