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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Judge RA"

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EMD-40571

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Cryo-EM structure of PAPP-A2

Release date: Nov. 8, 2023
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8sl1
Q-score: 0.466

Sridar J, Mafi A, Judge RA, Xu J, Kong KA, Wang JCK, Stoll VS, Koukos G, Simon RJ, Eaton D, Bratkowski M, Hao Q

Commun Chem (2023) 6 pp. 234-234 [ Pubmed: 37898658 DOI: doi:10.1038/s42004-023-01032-y ]

Sample:

Papp-a2 (Complex from Homo sapiens)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Water (18 Da, Ligand)
Zinc ion (65 Da, Ligand)
Pappalysin-2 (174 kDa, Protein from Homo sapiens)
Calcium ion (40 Da, Ligand)

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EMD-26475

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Cryo-EM structure of PAPP-A in complex with IGFBP5

Release date: Sept. 28, 2022
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7ufg
Q-score: 0.443

Judge RA, Sridar J, Tunyasunvunakool K, Jain R, Wang JCK, Ouch C, Xu J, Mafi A, Nile AH, Remarcik C, Smith CL, Ghosh C, Xu C, Stoll V, Jumper J, Singh AH, Eaton D, Hao Q

Nat Commun (2022) 13 pp. 5500- [ Pubmed: 36127359 DOI: doi:10.1038/s41467-022-33175-2 ]

Sample:

Zinc ion (65 Da, Ligand)
Complex of papp-a with igfbp5 (Complex from Homo sapiens)
Pappalysin-1 (176 kDa, Protein from Homo sapiens)
Insulin-like growth factor-binding protein 5 (30 kDa, Protein from Homo sapiens)

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EMD-27253

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Cryo-EM structure of substrate unbound PAPP-A

Release date: Sept. 28, 2022
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8d8o
Q-score: 0.44

Judge RA, Sridar J, Tunyasunvunakool K, Jain R, Wang JCK, Ouch C, Xu J, Mafi A, Nile AH, Remarcik C, Smith CL, Ghosh C, Xu C, Stoll V, Jumper J, Singh AH, Eaton D, Hao Q

Nat Commun (2022) 13 pp. 5500- [ Pubmed: 36127359 DOI: doi:10.1038/s41467-022-33175-2 ]

Sample:

Papp-a homodimer (Complex from Homo sapiens)
Zinc ion (65 Da, Ligand)
Pappalysin-1 (176 kDa, Protein from Homo sapiens)

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