Chaetomium thermophilum SETX - NPPC internal deletion
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8fth
Q-score: 0.479
Appel CD, Bermek O, Dandey VP, Wood M, Viverette E, Williams JG, Bouvette J, Riccio AA, Krahn JM, Borgnia MJ, Williams RS
Mol Cell (2023) 83 pp. 3692- [ Pubmed: 37832548 DOI: doi:10.1016/j.molcel.2023.09.024 ]
Chaetomium thermophilum SETX (Full-length)
Resolution: 4.56 Å
EM Method: Single-particle
Fitted PDBs: 8ftk
Q-score: 0.288
Appel CD, Bermek O, Dandey VP, Wood M, Viverette E, Williams JG, Bouvette J, Riccio AA, Krahn JM, Borgnia MJ, Williams RS
Mol Cell (2023) 83 pp. 3692- [ Pubmed: 37832548 DOI: doi:10.1016/j.molcel.2023.09.024 ]
Appel CD, Bermek O, Dandey VP, Wood M, Viverette E, Williams JG, Bouvette J, Riccio AA, Krahn JM, Borgnia MJ, Williams RS
Mol Cell (2023) 83 pp. 3692-3706.e5 [ Pubmed: 37832548 DOI: doi:10.1016/j.molcel.2023.09.024 ]
Human tRNA Splicing Endonuclease Complex bound to 2'F-tRNA-Arg
Hayne CK, Butay KJU, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch RM, Deterding LJ, Matera AG, Borgnia MJ, Stanley RE
Nat Struct Mol Biol (2023) 30 pp. 824-833 [ DOI: doi:10.1038/s41594-023-00991-z Pubmed: 37231153 ]
Human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7uxa
Q-score: 0.472
Hayne CK, Butay KJU, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch RM, Deterding LJ, Matera AG, Borgnia MJ, Stanley RE
Nat Struct Mol Biol (2023) 30 pp. 824-833 [ DOI: doi:10.1038/s41594-023-00991-z Pubmed: 37231153 ]
- Trna-splicing endonuclease subunit sen34 (37 kDa, Protein from Homo sapiens)
- Trna-splicing endonuclease subunit sen2 (55 kDa, Protein from Homo sapiens)
- Trna-splicing endonuclease subunit sen15 (19 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Rna (78-mer) (28 kDa, RNA from synthetic construct)
- Trna-splicing endonuclease subunit sen54 (61 kDa, Protein from Homo sapiens)
- Human trna splicing endonuclease complex bound to pre-trna-arg (203 kDa, Complex from Homo sapiens)
Human Rix1 sub-complex scaffold
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7uwf
Q-score: 0.589
Gordon J, Chapus FL, Viverette EG, Williams JG, Deterding LJ, Krahn JM, Borgnia MJ, Rodriguez J, Warren AJ, Stanley RE
Nat Commun (2022) 13 pp. 6783-6783 [ DOI: doi:10.1038/s41467-022-34610-0 Pubmed: 36351913 ]
- Human rix1 sub-complex scaffold (236 MDa, Complex from Homo sapiens)
- Modulator of non-genomic activity of estrogen receptor (69 kDa, Protein from Homo sapiens)
- Wd repeat-containing protein 18 (49 kDa, Protein from Homo sapiens)
Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7u65
Q-score: 0.551
Klemm BP, Singh D, Smith CE, Hsu AL, Dillard LB, Krahn JM, London RE, Mueller GA, Borgnia MJ, Schaaper RM
PNAS (2022) 119 pp. e2123092119-e2123092119 [ DOI: doi:10.1073/pnas.2123092119 Pubmed: 36067314 ]
- Gene 1.2 protein (Complex from Escherichia phage T7)
- Dgtp triphosphohydrolase (Complex from Escherichia coli str. K-12 substr. MG1655)
- Inhibitor of dgtpase (10 kDa, Protein from Escherichia phage T7)
- Dgtpase hexamer bound to six copies of gp1.2 (Complex from Escherichia coli str. K-12 substr. MG1655)
- Deoxyguanosinetriphosphate triphosphohydrolase (59 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 and dGTP
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7u66
Q-score: 0.539
Klemm BP, Singh D, Smith CE, Hsu AL, Dillard LB, Krahn JM, London RE, Mueller GA, Borgnia MJ, Schaaper RM
PNAS (2022) 119 pp. e2123092119-e2123092119 [ DOI: doi:10.1073/pnas.2123092119 Pubmed: 36067314 ]
- Dgtpase hexamer bound to six copies of gp1.2 (Complex from Escherichia coli str. K-12 substr. MG1655)
- Inhibitor of dgtpase (10 kDa, Protein from Escherichia phage T7)
- Deoxyguanosinetriphosphate triphosphohydrolase (59 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- Gene 1.2 protein (Complex from Escherichia phage T7)
- 2'-deoxyguanosine-5'-triphosphate (507 Da, Ligand)
- Dgtp triphosphohydrolase (Complex from Escherichia coli str. K-12 substr. MG1655)
- Magnesium ion (24 Da, Ligand)
Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 and GTP
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7u67
Q-score: 0.588
Klemm BP, Singh D, Smith CE, Hsu AL, Dillard LB, Krahn JM, London RE, Mueller GA, Borgnia MJ, Schaaper RM
PNAS (2022) 119 pp. e2123092119-e2123092119 [ DOI: doi:10.1073/pnas.2123092119 Pubmed: 36067314 ]
- Dgtpase hexamer bound to six copies of gp1.2 (Complex from Escherichia coli str. K-12 substr. MG1655)
- Inhibitor of dgtpase (10 kDa, Protein from Escherichia phage T7)
- Deoxyguanosinetriphosphate triphosphohydrolase (59 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- Gene 1.2 protein (Complex from Escherichia phage T7)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Dgtp triphosphohydrolase (Complex from Escherichia coli str. K-12 substr. MG1655)
- Magnesium ion (24 Da, Ligand)
Octameric Human Twinkle Helicase Clinical Variant W315L
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7t8b
Q-score: 0.315
Riccio AA, Bouvette J, Perera L, Longley MJ, Krahn JM, Williams JG, Dutcher R, Borgnia MJ, Copeland WC
PNAS (2022) 119 pp. e2207459119-e2207459119 [ DOI: doi:10.1073/pnas.2207459119 Pubmed: 35914129 ]
- Twinkle mtdna helicase (78 kDa, Protein from Homo sapiens)
- Heptameric human twinkle clinical variant w315l (504 kDa, Complex from Homo sapiens)