Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8qxj
Q-score: 0.574
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ Pubmed: 38710701 DOI: doi:10.1038/s41467-024-48237-w ]
- 2'-deoxy-5'-o-[(r)-hydroxy{[(r)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine (490 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State I - Tense
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8qxk
Q-score: 0.62
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ Pubmed: 38710701 DOI: doi:10.1038/s41467-024-48237-w ]
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8qxl
Q-score: 0.541
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- 2'-deoxycytidine (227 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Triphosphate (257 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8qxm
Q-score: 0.573
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of tetrameric human SAMHD1 State IV - Depleted relaxed
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8qxn
Q-score: 0.459
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ Pubmed: 38710701 DOI: doi:10.1038/s41467-024-48237-w ]
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State V - Depleted relaxed
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8qxo
Q-score: 0.417
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ Pubmed: 38710701 DOI: doi:10.1038/s41467-024-48237-w ]
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8or0
Q-score: 0.218
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ Pubmed: 37339624 DOI: doi:10.1016/j.molcel.2023.05.034 ]
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinases regulatory subunit 1 (8 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinase 2 (33 kDa, Protein from Homo sapiens)
- Cand1-cul1-rbx1-skp1-skp2-cks1-cdk2 (Complex from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 2 (48 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8or2
Q-score: 0.368
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ Pubmed: 37339624 DOI: doi:10.1016/j.molcel.2023.05.034 ]
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- Dcn1-like protein 1 (30 kDa, Protein from Homo sapiens)
- Cand1-cul1-rbx1-dcnl1 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8or3
Q-score: 0.415
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ DOI: doi:10.1016/j.molcel.2023.05.034 Pubmed: 37339624 ]
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Dcn1-like protein 1 (30 kDa, Protein from Homo sapiens)
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cand1-cul1-rbx1-skp1-skp2-cks1-cdk2-cycline-dcnl1 (Complex from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 2 (48 kDa, Protein from Homo sapiens)
Partially dissociated CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8or4
Q-score: 0.285
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ Pubmed: 37339624 DOI: doi:10.1016/j.molcel.2023.05.034 ]
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinases regulatory subunit 1 (8 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinase 2 (33 kDa, Protein from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- Partially dissociated cand1-cul1-rbx1-skp1-skp2-cks1-cdk2 (Complex from Homo sapiens)
- S-phase kinase-associated protein 2 (48 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)