Structure of the human CLC-7/Ostm1 complex reveals a novel state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8hvt
Q-score: 0.498
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Osteopetrosis-associated transmembrane protein 1 (37 kDa, Protein from Homo sapiens)
- H(+)/cl(-) exchange transporter 7 (88 kDa, Protein from Homo sapiens)
- Clc-7/ostm1 (Complex from Homo sapiens)
Human VMAT2 in complex with tetrabenazine
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8t69
Q-score: 0.558
Pidathala S, Liao S, Dai Y, Li X, Long C, Chang CL, Zhang Z, Lee CH
Nature (2023) 623 pp. 1086-1092 [ Pubmed: 37914936 DOI: doi:10.1038/s41586-023-06727-9 ]
- Human vmat2 in complex with tetrabenazine (Complex from Homo sapiens)
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
- Tetrabenazine (317 Da, Ligand)
Human VMAT2 in complex with reserpine
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8t6a
Q-score: 0.504
Pidathala S, Liao S, Dai Y, Li X, Long C, Chang CL, Zhang Z, Lee CH
Nature (2023) 623 pp. 1086-1092 [ Pubmed: 37914936 DOI: doi:10.1038/s41586-023-06727-9 ]
- Human vmat2 in complex with reserpine (Complex from Homo sapiens)
- Reserpine (608 Da, Ligand)
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
Human VMAT2 in complex with serotonin
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8t6b
Q-score: 0.39
Pidathala S, Liao S, Dai Y, Li X, Long C, Chang CL, Zhang Z, Lee CH
Nature (2023) 623 pp. 1086-1092 [ Pubmed: 37914936 DOI: doi:10.1038/s41586-023-06727-9 ]
- Human vmat2 in complex with serotonin (Complex from Homo sapiens)
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
The EGF-bound EGFR ectodomain homodimer
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8hgs
Q-score: 0.245
Bai X, Sun P, Wang X, Long C, Liao S, Dang S, Zhuang S, Du Y, Zhang X, Li N, He K, Zhang Z
Cell Discov (2023) 9 pp. 18-18 [ DOI: doi:10.1038/s41421-023-00523-5 Pubmed: 36781849 ]
- Epidermal growth factor receptor (81 kDa, Protein from Homo sapiens)
- Egf-bound egfr ectodomain homodimer (200 kDa, Complex from Homo sapiens)
- Pro-epidermal growth factor (6 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
The EGF-bound EGFR/HER2 ectodomain complex
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8hgo
Q-score: 0.331
Bai X, Sun P, Wang X, Long C, Liao S, Dang S, Zhuang S, Du Y, Zhang X, Li N, He K, Zhang Z
Cell Discov (2023) 9 pp. 18-18 [ Pubmed: 36781849 DOI: doi:10.1038/s41421-023-00523-5 ]
- Epidermal growth factor receptor (81 kDa, Protein from Homo sapiens)
- Egf-bound egfr/her2 ectodomain complex (200 kDa, Complex from Homo sapiens)
- Epidermal growth factor (6 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Receptor tyrosine-protein kinase erbb-2 (82 kDa, Protein from Homo sapiens)
The EREG-bound EGFR/HER2 ectodomain complex
Resolution: 4.53 Å
EM Method: Single-particle
Fitted PDBs: 8hgp
Q-score: 0.17
Bai X, Sun P, Wang X, Long C, Liao S, Dang S, Zhuang S, Du Y, Zhang X, Li N, He K, Zhang Z
Cell Discov (2023) 9 pp. 18-18 [ DOI: doi:10.1038/s41421-023-00523-5 Pubmed: 36781849 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ereg-bound egfr/her2 ectodomain complex (200 kDa, Complex from Homo sapiens)
- Epidermal growth factor receptor (81 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (82 kDa, Protein from Homo sapiens)
- Proepiregulin (5 kDa, Protein from Homo sapiens)