Cryo-EM structure of human CALHM2 in an active/open state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6uiv
Q-score: 0.422
Choi W, Clemente N, Sun W, Du J, Lu W
Nature (2019) 576 pp. 163-167 [ DOI: doi:10.1038/s41586-019-1781-3 Pubmed: 31776515 ]
- Human calhm2 (Complex from Homo sapiens)
- Calcium homeostasis modulator protein 2 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of human CALHM2 in a ruthenium red-bound inhibited state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6uiw
Q-score: 0.523
Choi W, Clemente N, Sun W, Du J, Lu W
Nature (2019) 576 pp. 163-167 [ DOI: doi:10.1038/s41586-019-1781-3 Pubmed: 31776515 ]
- Ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) (559 Da, Ligand)
- Human calhm2 (Complex from Homo sapiens)
- Calcium homeostasis modulator protein 2 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of human CALHM2 gap junction
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6uix
Q-score: 0.382
Choi W, Clemente N, Sun W, Du J, Lu W
Nature (2019) 576 pp. 163-167 [ DOI: doi:10.1038/s41586-019-1781-3 Pubmed: 31776515 ]
- Human calhm2 (Complex from Homo sapiens)
- Calcium homeostasis modulator protein 2 (37 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6puo
Q-score: 0.457
eLife (2019) 8 [ Pubmed: 31513012 DOI: doi:10.7554/eLife.50175 ]
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6pur
Q-score: 0.301
eLife (2019) 8 [ Pubmed: 31513012 DOI: doi:10.7554/eLife.50175 ]
- Human trpm2 (Complex from Homo sapiens)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 2 (172 kDa, Protein from Homo sapiens)
Human TRPM2 bound to ADPR and calcium
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6pus
Q-score: 0.393
eLife (2019) 8 [ Pubmed: 31513012 DOI: doi:10.7554/eLife.50175 ]
- Human trpm2 (Complex from Homo sapiens)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 2 (172 kDa, Protein from Homo sapiens)
Human TRPM2 bound to 8-Br-cADPR and calcium
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6puu
Q-score: 0.427
eLife (2019) 8 [ Pubmed: 31513012 DOI: doi:10.7554/eLife.50175 ]
- Human trpm2 (Complex from Homo sapiens)
- (2r,3r,4s,5r,13r,14s,15r,16r)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide (621 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 2 (172 kDa, Protein from Homo sapiens)