EMDB < Search results

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Maruthi K" AND assembly_molecular_weight:{500000 TO 1000000] AND author_orcid:"0000-0001-5492-0652" AND author_orcid:"0000-0002-8014-7269" AND author_orcid:"0000-0001-8265-5761"

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EMD-24432

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SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer

Release date: Nov. 24, 2021
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 7re3
Q-score: 0.321

Chen J, Wang Q, Malone B, Llewellyn E, Pechersky Y, Maruthi K, Eng ET, Perry JK, Campbell EA, Shaw DE, Darst SA

Nat Struct Mol Biol (2022) 29 pp. 250-260 [ DOI: doi:10.1038/s41594-022-00734-6 Pubmed: 35260847 ]

Sample:

Product rna (11 kDa, RNA from synthetic construct)
Sars-cov-2 replication/transcription complex bound to nsp13 helicase - nsp13(2)-rtc dimer (Complex from Severe acute respiratory syndrome coronavirus 2)
Template rna (17 kDa, RNA from synthetic construct)
Chapso (631 Da, Ligand)
Non-structural protein 8 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Aluminum fluoride (83 Da, Ligand)
Rna-directed rna polymerase (106 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Adenosine-5'-diphosphate (427 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Zinc ion (65 Da, Ligand)
Helicase (67 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)

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