Structure of TbAQP2 in complex with anti-trypanosomatid drug melarsoprol
Structure of the TbAQP2 in the apo conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jy7
Q-score: 0.53
Chen W, Zou R, Mei Y, Li J, Xuan Y, Cui B, Zou J, Wang J, Lin S, Zhang Z, Wang C
Nat Commun (2024) 15 pp. 3985-3985 [ DOI: doi:10.1038/s41467-024-48445-4 Pubmed: 38734677 ]
- Aquaglyceroporin 2 (36 kDa, Protein from Trypanosoma brucei brucei)
- Tetramer of tbaqp2 (Complex from Trypanosoma brucei brucei)
Structure of TbAQP2 in complex with anti-trypanosomatid drug pentamidine
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 8jy8
Q-score: 0.611
Chen W, Zou R, Mei Y, Li J, Xuan Y, Cui B, Zou J, Wang J, Lin S, Zhang Z, Wang C
Nat Commun (2024) 15 pp. 3985-3985 [ Pubmed: 38734677 DOI: doi:10.1038/s41467-024-48445-4 ]
- Aquaglyceroporin 2 (33 kDa, Protein from Trypanosoma brucei brucei)
- Tbaqp2 complex with pentamidine (Complex from Trypanosoma brucei brucei)
- 1,5-bis(4-amidinophenoxy)pentane (340 Da, Ligand)
EBNA1 DNA binding domain (DBD) (458-617)+2 repeats of family repeat (FR) region
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8dlf
Q-score: 0.308
Mei Y, Messick TE, Dheekollu J, Kim HJ, Molugu S, Munoz LJC, Moiskeenkova-Bell V, Murakami K, Lieberman PM
J Virol (2022) 96 pp. e0094922-e0094922 [ Pubmed: 36037477 DOI: doi:10.1128/jvi.00949-22 ]
- Epstein-barr nuclear antigen 1 (17 kDa, Protein from Human herpesvirus 4 strain B95-8)
- Ebna1 dbd+2xfr complex (Complex from Human herpesvirus 4 strain B95-8)
- Water (18 Da, Ligand)
- 2xfr dna (56-mer) (17 kDa, DNA from Human herpesvirus 4 strain B95-8)
- 2xfr dna (56-mer) (17 kDa, DNA from Human herpesvirus 4 strain B95-8)
EBNA1 DNA binding domain (401-641) binds to half Dyad Symmetry element
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7u1t
Q-score: 0.299
To Be Published
- Ebna1 dna binding domain binds to half dyad symmetry region (160 kDa, Complex from Human herpesvirus 4 strain B95-8)
- Dna (59-mer) (18 kDa, DNA from Human herpesvirus 4 strain B95-8)
- Epstein-barr nuclear antigen 1 (19 kDa, Protein from Human herpesvirus 4 strain B95-8)
- Dna (59-mer) (18 kDa, DNA from Human herpesvirus 4 strain B95-8)
Atomic structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes
Resolution: 9.0 Å
EM Method: Single-particle
Fitted PDBs: 6q1f
Q-score: 0.213
Zhang Y, Liu W, Li Z, Kumar V, Alvarez-Cabrera AL, Leibovitch EC, Cui Y, Mei Y, Bi GQ, Jacobson S, Zhou ZH
Nat Commun (2019) 10 pp. 5346-5346 [ DOI: doi:10.1038/s41467-019-13064-x Pubmed: 31767868 ]
- Human herpesvirus 6 strain z29 (Virus from Human herpesvirus 6 strain Z29)
- Triplex capsid protein 1 (34 kDa, Protein from Human herpesvirus 6B (strain Z29))
- Triplex capsid protein 2 (33 kDa, Protein from Human herpesvirus 6B (strain Z29))
- Large structural phosphoprotein (95 kDa, Protein from Human herpesvirus 6B (strain Z29))
- Small capsomere-interacting protein (9 kDa, Protein from Human herpesvirus 6B (strain Z29))
- Major capsid protein (152 kDa, Protein from Human herpesvirus 6B (strain Z29))
Atomic Structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes
Zhang Y, Liu W, Li Z, Kumar V, Alvarez-Cabrera AL, Leibovitch EC, Cui Y, Mei Y, Bi GQ, Jacobson S, Zhou ZH
Nat Commun (2019) 10 pp. 5346-5346 [ Pubmed: 31767868 DOI: doi:10.1038/s41467-019-13064-x ]
Atomic Structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes
Zhang Y, Liu W, Li Z, Kumar V, Alvarez-Cabrera AL, Leibovitch EC, Cui Y, Mei Y, Bi GQ, Jacobson S, Zhou ZH
Nat Commun (2019) 10 pp. 5346-5346 [ Pubmed: 31767868 DOI: doi:10.1038/s41467-019-13064-x ]
Atomic Structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes
Zhang Y, Liu W, Li Z, Kumar V, Alvarez-Cabrera AL, Leibovitch EC, Cui Y, Mei Y, Bi GQ, Jacobson S, Zhou ZH
Nat Commun (2019) 10 pp. 5346-5346 [ Pubmed: 31767868 DOI: doi:10.1038/s41467-019-13064-x ]
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 6nhj
Q-score: 0.139
Liu W, Dai X, Jih J, Chan K, Trang P, Yu X, Balogun R, Mei Y, Liu F, Zhou ZH
PLoS Pathog (2019) 15 pp. e1007615-e1007615 [ Pubmed: 30779794 DOI: doi:10.1371/journal.ppat.1007615 ]
- Murid herpesvirus 1 (strain smith) (Virus from Murid herpesvirus 1 (strain Smith))
- Small capsomere-interacting protein (9 kDa, Protein from MuHV-1)
- Major capsid protein (151 kDa, Protein from MuHV-1)
- Tegument protein (78 kDa, Protein from MuHV-1)
- Minor capsid protein (33 kDa, Protein from MuHV-1)
- Triplex capsid protein 2 (34 kDa, Protein from MuHV-1)