Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Qi Y" AND author_name:"Xu Y" AND author_orcid:"0000-0003-3754-2623"

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EMD-30473

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The structure of human Integrator-PP2A complex

Release date: Nov. 25, 2020
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7cun
Q-score: 0.35

Zheng H, Qi Y, Hu S, Cao X, Xu C, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX, Xu Y

Science (2020) 370 [ DOI: doi:10.1126/science.abb5872 Pubmed: 33243860 ]

Sample:

Integrator complex subunit 1 (244 kDa, Protein from Homo sapiens)
Integrator complex subunit 7 (106 kDa, Protein from Homo sapiens)
Unknown subunit (Complex from Homo sapiens)
Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
Pp2a-c (35 kDa, Protein from Homo sapiens)
Integrator complex subunit 11 (67 kDa, Protein from Homo sapiens)
Manganese (ii) ion (54 Da, Ligand)
Human integrator-pp2a complex (Complex)
Integrator complex subunit 6 (100 kDa, Protein from Homo sapiens)
Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
Pp2a-a (66 kDa, Protein from Homo sapiens)
Unknown (50 kDa, Protein from Homo sapiens)
Integrator complex subunit 4 (108 kDa, Protein from Homo sapiens)
Pp2a (Complex from Homo sapiens)
Integrator complex subunit 1, 2, 4, 5, 6, 7, 8, 9, 11 (Complex from Homo sapiens)
Zinc ion (65 Da, Ligand)
Integrator complex subunit 2 (134 kDa, Protein from Homo sapiens)

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