Cryo-EM structure of the apo CCR3-Gi complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7x9y
Q-score: 0.375
Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H
Cell Discov (2022) 8 pp. 44-44 [ DOI: doi:10.1038/s41421-022-00403-4 Pubmed: 35570218 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C-c chemokine receptor type 3 (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo ccr3-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the CCL2 bound CCR2-Gi complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7xa3
Q-score: 0.454
Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H
Cell Discov (2022) 8 pp. 44-44 [ DOI: doi:10.1038/s41421-022-00403-4 Pubmed: 35570218 ]
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Isoform b of c-c chemokine receptor type 2 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C-c motif chemokine 2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo ccr3-gi complex (Complex from Homo sapiens)
Cryo-EM structure of the Apo CCR1-Gi complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7vl8
Q-score: 0.454
Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H
Nat Chem Biol (2022) 18 pp. 264-271 [ DOI: doi:10.1038/s41589-021-00918-z Pubmed: 34949837 ]
- Cholesterol (386 Da, Ligand)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Apo form ccr1-gi complex (Complex from Homo sapiens)
- C-c chemokine receptor type 1 (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7vl9
Q-score: 0.563
Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H
Nat Chem Biol (2022) 18 pp. 264-271 [ DOI: doi:10.1038/s41589-021-00918-z Pubmed: 34949837 ]
- Cholesterol (386 Da, Ligand)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Ccl15(26-92)-bound ccr1-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Ccl15(26-92) (8 kDa, Protein from Homo sapiens)
- C-c chemokine receptor type 1 (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7vla
Q-score: 0.561
Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H
Nat Chem Biol (2022) 18 pp. 264-271 [ Pubmed: 34949837 DOI: doi:10.1038/s41589-021-00918-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Ccl15(27-92)-bound ccr1-gi complex (Complex from Homo sapiens)
- C-c chemokine receptor type 1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ccl15(27-92) (8 kDa, Protein from Homo sapiens)
Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7w2z
Q-score: 0.564
Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z
Nat Commun (2022) 13 pp. 300-300 [ Pubmed: 35027551 DOI: doi:10.1038/s41467-022-27975-9 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Appetite-regulating hormone (1 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Growth hormone secretagogue receptor type 1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Appetite-regulating hormone (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (26 kDa, Protein from Homo sapiens)
- Cryo-em structure of the ghrelin-bound human ghrelin receptor-go complex (160 MDa, Complex from Homo sapiens)
- Scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(o) subunit alpha, growth hormone secretagogue receptor type 1 (Complex from Homo sapiens)