CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8or0
Q-score: 0.218
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ Pubmed: 37339624 DOI: doi:10.1016/j.molcel.2023.05.034 ]
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinases regulatory subunit 1 (8 kDa, Protein from Homo sapiens)
- Cyclin-dependent kinase 2 (33 kDa, Protein from Homo sapiens)
- Cand1-cul1-rbx1-skp1-skp2-cks1-cdk2 (Complex from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 2 (48 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8or2
Q-score: 0.368
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ Pubmed: 37339624 DOI: doi:10.1016/j.molcel.2023.05.034 ]
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- Dcn1-like protein 1 (30 kDa, Protein from Homo sapiens)
- Cand1-cul1-rbx1-dcnl1 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8or3
Q-score: 0.415
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Maeots ME, Maslen SL, Skehel JM, Enchev RI
Mol Cell (2023) 83 pp. 2332- [ DOI: doi:10.1016/j.molcel.2023.05.034 Pubmed: 37339624 ]
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Dcn1-like protein 1 (30 kDa, Protein from Homo sapiens)
- Cullin-associated nedd8-dissociated protein 1 (137 kDa, Protein from Homo sapiens)
- Cullin-1 (93 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cand1-cul1-rbx1-skp1-skp2-cks1-cdk2-cycline-dcnl1 (Complex from Homo sapiens)
- S-phase kinase-associated protein 1 (18 kDa, Protein from Homo sapiens)
- S-phase kinase-associated protein 2 (48 kDa, Protein from Homo sapiens)
Polymerase module of CPF in complex with Mpe1 and a pre-cleaved CYC1 RNA
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7zgp
Q-score: 0.624
Rodriguez-Molina JB, O'Reilly FJ, Fagarasan H, Sheekey E, Maslen S, Skehel JM, Rappsilber J, Passmore LA
Mol Cell (2022) 82 pp. 2490- [ Pubmed: 35584695 DOI: doi:10.1016/j.molcel.2022.04.021 ]
- Polyadenylation factor subunit 2 (53 kDa, Protein from Saccharomyces cerevisiae)
- Pre-cleaved cyc1 (13 kDa, RNA from Saccharomyces cerevisiae)
- Mrna 3'-end-processing protein yth1 (24 kDa, Protein from Saccharomyces cerevisiae)
- Mpe1 isoform 1 (49 kDa, Protein from Saccharomyces cerevisiae)
- Protein cft1 (153 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Polymerase module-mpe1-rna (Complex from Saccharomyces cerevisiae)
Polymerase module of yeast CPF in complex with Mpe1, the yPIM of Cft2 and the pre-cleaved CYC1 RNA
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7zgr
Q-score: 0.61
Rodriguez-Molina JB, O'Reilly FJ, Fagarasan H, Sheekey E, Maslen S, Skehel JM, Rappsilber J, Passmore LA
Mol Cell (2022) 82 pp. 2490- [ Pubmed: 35584695 DOI: doi:10.1016/j.molcel.2022.04.021 ]
- Polyadenylation factor subunit 2 (53 kDa, Protein from Saccharomyces cerevisiae)
- Mrna 3'-end-processing protein yth1 (24 kDa, Protein from Saccharomyces cerevisiae)
- Cleavage factor two protein 2 (80 kDa, Protein from Saccharomyces cerevisiae)
- Mpe1 isoform 1 (49 kDa, Protein from Saccharomyces cerevisiae)
- Protein cft1 (153 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Pre-cleaved cyc1 (13 kDa, RNA from Saccharomyces cerevisiae)
- Polymerase module-mpe1-ypim-rna (Complex from Saccharomyces cerevisiae)
Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 7ole
Q-score: 0.143
Pal M, Munoz-Hernandez H, Bjorklund D, Zhou L, Degliesposti G, Skehel JM, Hesketh EL, Thompson RF, Pearl LH, Llorca O, Prodromou C
Cell Rep (2021) 36 pp. 109317-109317 [ Pubmed: 34233195 DOI: doi:10.1016/j.celrep.2021.109317 ]
- Telomere length regulation protein tel2 homolog (53 kDa, Protein from Homo sapiens)
- Ruvb-like 2 (51 kDa, Protein from Homo sapiens)
- Ruvb-like 1 (50 kDa, Protein from Homo sapiens)
- Telo2-tti1-tti2-ruvbl1-ruvbl2 complex (580 kDa, Complex)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Telo2-interacting protein 2,telo2-interacting protein 2,tti2 (95 kDa, Protein from Homo sapiens)
- Telo2-interacting protein 1 homolog,telo2-interacting protein 1 homolog,tti1 (176 kDa, Protein from Homo sapiens)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6zhx
Q-score: 0.625
Lehmann LC, Bacic L, Hewitt G, Brackmann K, Sabantsev A, Gaullier G, Pytharopoulou S, Degliesposti G, Okkenhaug H, Tan S, Costa A, Skehel JM, Boulton SJ, Deindl S
Cell Rep (2020) 33 pp. 108529-108529 [ Pubmed: 33357431 DOI: doi:10.1016/j.celrep.2020.108529 ]
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Dna (Complex from synthetic construct)
- Histones (Complex from Xenopus laevis)
- Dna (145-mer) widom 601 sequence (44 kDa, DNA from synthetic construct)
- Chromodomain-helicase-dna-binding protein 1-like (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Chromodomain-helicase-dna-binding protein 1-like (4 kDa, Protein from Homo sapiens)
- Histone h3 (15 kDa, Protein from Xenopus laevis)
- Dna (145-mer) widom 601 sequence (44 kDa, DNA from synthetic construct)
- Crosslinked complex of alc1 regulatory linker and the nucleosome (206 kDa, Complex)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
Structure of a human 48S translational initiation complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6zmw
Q-score: 0.293
Brito Querido J, Sokabe M, Kraatz S, Gordiyenko Y, Skehel JM, Fraser CS, Ramakrishnan V
Science (2020) 369 pp. 1220-1227 [ Pubmed: 32883864 DOI: doi:10.1126/science.aba4904 ]
- Eukaryotic translation initiation factor 3 subunit h (39 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit k (25 kDa, Protein from Homo sapiens)
- Eukaryotic initiation factor 4a-i (46 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit m (42 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit a (166 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit g (35 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit b (92 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 4 gamma 1 (145 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit d (64 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit l (66 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- Initiator met-trna-i (24 kDa, RNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 1a, x-chromosomal (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit j (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
- 18s rrna (603 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Mrna (9 kDa, RNA from Homo sapiens)
- Eukaryotic translation initiation factor 1 (12 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit c (105 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 2 (38 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 3 (51 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit f (37 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit i (36 kDa, Protein from Homo sapiens)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- 48s initiation complex (Complex)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit e (52 kDa, Protein from Homo sapiens)
- 48s initiation complex (Complex from Homo sapiens)
Structure of a human 48S translational initiation complex - head
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6ybs
Q-score: 0.529
Brito Querido J, Sokabe M, Kraatz S, Gordiyenko Y, Skehel JM, Fraser CS, Ramakrishnan V
Science (2020) 369 pp. 1220-1227 [ Pubmed: 32883864 DOI: doi:10.1126/science.aba4904 ]
- Eukaryotic translation initiation factor 3 subunit g (35 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
- 18s rrna (603 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit d (64 kDa, Protein from Homo sapiens)
- 48s initiation complex (Complex from Homo sapiens)
Structure of a human 48S translational initiation complex - 40S body
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6ybw
Q-score: 0.517
Brito Querido J, Sokabe M, Kraatz S, Gordiyenko Y, Skehel JM, Fraser CS, Ramakrishnan V
Science (2020) 369 pp. 1220-1227 [ Pubmed: 32883864 DOI: doi:10.1126/science.aba4904 ]
- 40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 1a, x-chromosomal (16 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit j (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
- 18s rrna (603 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Mrna (9 kDa, RNA from Homo sapiens)
- Eukaryotic translation initiation factor 1 (12 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit c (105 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
- Human 48s initiation complex (Complex)
- 40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- Human 48s initiation complex (Complex from Homo sapiens)