Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP2
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8t3k
Q-score: 0.418
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Heterodimeric bmrcd with ligands atp and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ATP: BmrCD_OC-ATP
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8fhk
Q-score: 0.454
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Magnesium ion (24 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Heterodimeric bmrcd with ligands atp and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8fmv
Q-score: 0.489
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Heterodimeric bmrcd with ht1, atp, mg2+ and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
- Magnesium ion (24 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-benzimidazole (452 Da, Ligand)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8szc
Q-score: 0.494
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ DOI: doi:10.1038/s41467-023-42937-5 Pubmed: 37938578 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-benzimidazole (452 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Heterodimeric bmrcd with ligands atp and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8t1p
Q-score: 0.526
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Adp orthovanadate (544 Da, Ligand)
- Heterodimeric bmrcd with ligands atp/aov and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (Protein from Bacillus subtilis subsp. subtilis str. 168)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (Protein from Bacillus subtilis subsp. subtilis str. 168)
- Heterodimeric bmrcd with ligands atp/aov and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation
Resolution: 7.0 Å
EM Method: Single-particle
Fitted PDBs: 5iou
Q-score: 0.223
Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E
Cell (2016) 165 pp. 704-714 [ Pubmed: 27062927 DOI: doi:10.1016/j.cell.2016.03.028 ]
- Glutamic acid (147 Da, Ligand)
- Glun1-glun2b nmda receptor (Cellular component from Xenopus laevis)
- Glycine (75 Da, Ligand)
- Ionotropic glutamate receptor subunit nr2b (93 kDa, Protein from Xenopus laevis)
- N-methyl-d-aspartate receptor subunit nr1-8a (92 kDa, Protein from Xenopus laevis)
Resolution: 7.5 Å
EM Method: Single-particle
Fitted PDBs: 5iov
Q-score: 0.203
Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E
Cell (2016) 165 pp. 704-714 [ Pubmed: 27062927 DOI: doi:10.1016/j.cell.2016.03.028 ]
- Glun1-glun2b receptor in the complex with glycine and glutamate plus allosteric inhibitor ro25-6981 (Cellular component from Xenopus laevis)
- Glutamic acid (147 Da, Ligand)
- Ionotropic glutamate receptor subunit nr2b (93 kDa, Protein from Xenopus laevis)
- N-methyl-d-aspartate receptor subunit nr1-8a (92 kDa, Protein from Xenopus laevis)
- Glycine (75 Da, Ligand)
- 4-[(1r,2s)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol (339 Da, Ligand)
Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 2
Resolution: 13.5 Å
EM Method: Single-particle
Fitted PDBs: 5ipq
Q-score: 0.085
Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E
Cell (2016) 165 pp. 704-714 [ Pubmed: 27062927 DOI: doi:10.1016/j.cell.2016.03.028 ]
Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 3
Resolution: 14.1 Å
EM Method: Single-particle
Fitted PDBs: 5ipr
Q-score: 0.086
Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E
Cell (2016) 165 pp. 704-714 [ Pubmed: 27062927 DOI: doi:10.1016/j.cell.2016.03.028 ]