Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Stoll VS"

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EMD-40571

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Cryo-EM structure of PAPP-A2

Release date: Nov. 8, 2023
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8sl1
Q-score: 0.466

Sridar J, Mafi A, Judge RA, Xu J, Kong KA, Wang JCK, Stoll VS, Koukos G, Simon RJ, Eaton D, Bratkowski M, Hao Q

Commun Chem (2023) 6 pp. 234-234 [ Pubmed: 37898658 DOI: doi:10.1038/s42004-023-01032-y ]

Sample:

Papp-a2 (Complex from Homo sapiens)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Water (18 Da, Ligand)
Zinc ion (65 Da, Ligand)
Pappalysin-2 (174 kDa, Protein from Homo sapiens)
Calcium ion (40 Da, Ligand)

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EMD-22924

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Sugar phosphate activation of the stress sensor eIF2B

Release date: July 14, 2021
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 7kmf
Q-score: 0.527

Hao Q, Heo JM, Nocek BP, Hicks KG, Stoll VS, Remarcik C, Hackett S, LeBon L, Jain R, Eaton D, Rutter J, Wong YL, Sidrauski C

Nat Commun (2021) 12 pp. 3440-3440 [ DOI: doi:10.1038/s41467-021-23836-z Pubmed: 34103529 ]

Sample:

6-o-phosphono-beta-d-fructofuranose (260 Da, Ligand)
Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
Water (18 Da, Ligand)
Tranlation initiation factor eif-2b (Complex from Homo sapiens)
Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
Translation initiation factor eif-2b subunit alpha (40 kDa, Protein from Homo sapiens)
Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)

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