Resolution: 2.39 Å
EM Method: Single-particle
Fitted PDBs: 8teo
Q-score: 0.632
Stix R, Tan XF, Bae C, Fernandez-Marino AI, Swartz KJ, Faraldo-Gomez JD
Sci Adv (2023) 9 pp. eadj5539-eadj5539 [ Pubmed: 38064553 DOI: doi:10.1126/sciadv.adj5539 ]
- Voltage-gated potassium channel shaker (Cell from Drosophila melanogaster)
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Potassium voltage-gated channel protein shaker (74 kDa, Protein from Drosophila melanogaster)
CryoEM structure of rat Kv2.1(1-598) wild type in nanodiscs
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8sd3
Q-score: 0.534
Fernandez-Marino AI, Tan XF, Bae C, Huffer K, Jiang J, Swartz KJ
Nature (2023) 622 pp. 410-417 [ DOI: doi:10.1038/s41586-023-06582-8 Pubmed: 37758949 ]
- Potassium voltage-gated channel subfamily b member 1 (68 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Voltage-dependent potassium channel kv2.1 (Complex from Rattus norvegicus)
- Potassium ion (39 Da, Ligand)
CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8sda
Q-score: 0.478
Fernandez-Marino AI, Tan XF, Bae C, Huffer K, Jiang J, Swartz KJ
Nature (2023) 622 pp. 410-417 [ DOI: doi:10.1038/s41586-023-06582-8 Pubmed: 37758949 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Potassium voltage-gated channel subfamily b member 1 (68 kDa, Protein from Rattus norvegicus)
- Potassium ion (39 Da, Ligand)
- Voltage-dependent potassium channel kv2.1 l403a mutant (Complex from Rattus norvegicus)
Rat TRPV2 bound with 1 CBD ligand in nanodiscs
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8slx
Q-score: 0.497
Gochman A, Tan XF, Bae C, Chen H, Swartz KJ, Jara-Oseguera A
eLife (2023) 12 [ DOI: doi:10.7554/eLife.86166 Pubmed: 37199723 ]
- Cannabidiol (314 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Trpv2 with cbd ligand (Cell from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
Rat TRPV2 bound with 2 CBD ligands in nanodiscs
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8sly
Q-score: 0.524
Gochman A, Tan XF, Bae C, Chen H, Swartz KJ, Jara-Oseguera A
eLife (2023) 12 [ DOI: doi:10.7554/eLife.86166 Pubmed: 37199723 ]
- Cannabidiol (314 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Trpv2 with cbd ligand (Cell from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
Human Kv1.3 with A0194009G09 nanobodies
Selvakumar P, Fernández-Mariño AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR
Nat Commun (2022) 13 [ Pubmed: 35788586 DOI: 10.1038/s41467-022-31285-5 ]
Image sets:
Human Kv1.3 with a Fab-ShK fusion
Selvakumar P, Fernández-Mariño AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR
Nat Commun (2022) 13 [ Pubmed: 35788586 DOI: 10.1038/s41467-022-31285-5 ]
Image sets:
Selvakumar P, Fernández-Mariño AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR
Nat Commun (2022) 13 [ Pubmed: 35788586 DOI: 10.1038/s41467-022-31285-5 ]
Image sets:
Structure of human Kv1.3 with Fab-ShK fusion
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 7ssv
Q-score: 0.441
Selvakumar P, Fernandez-Marino AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR
Nat Commun (2022) 13 pp. 3854-3854 [ DOI: doi:10.1038/s41467-022-31285-5 Pubmed: 35788586 ]
- Potassium ion (39 Da, Ligand)
- Potassium voltage-gated channel subfamily a member 3,green fluorescent protein fusion (95 kDa, Protein from Aequorea victoria)
- Kv1.3 with fab-shk (Complex from Homo sapiens)
- Fab-shk fusion, light chain (22 kDa, Protein from unidentified)
- Fab-shk fusion, heavy chain (29 kDa, Protein from unidentified)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7ssx
Q-score: 0.515
Selvakumar P, Fernandez-Marino AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR
Nat Commun (2022) 13 pp. 3854-3854 [ DOI: doi:10.1038/s41467-022-31285-5 Pubmed: 35788586 ]