Electron Microscopy Data Bank

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Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)

Release date: July 27, 2022
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7syf
Q-score: 0.205

Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2022) 29 pp. 767-773 [ DOI: doi:10.1038/s41594-022-00804-9 Pubmed: 35864164 ]

Sample:

Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 protein,endolysin chimera (191 kDa, Protein from Homo sapiens)
Full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1) (191 kDa, Complex from Homo sapiens)

EMD-25525

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Localised reconstruction of the N-terminal half of P-Rex1 (PI(3,4,5)P3-dependent Rac Exchanger 1)

Release date: July 27, 2022
Resolution: 4.4 Å
EM Method: Single-particle

Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2022) 29 pp. 767-773 [ DOI: doi:10.1038/s41594-022-00804-9 Pubmed: 35864164 ]

Sample:

N-terminal half of p-rex1 (pi(3,4,5)p3-dependent rac exchanger 1) (191 kDa, Complex from Homo sapiens)

EMD-25526

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Localised reconstruction of the C-terminal half of P-Rex 1 (PI(3,4,5)P3-dependent Rac Exchanger 1)

Release date: July 27, 2022
Resolution: 3.4 Å
EM Method: Single-particle

Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2022) 29 pp. 767-773 [ DOI: doi:10.1038/s41594-022-00804-9 Pubmed: 35864164 ]

Sample:

C-terminal half of p-rex 1 (pi(3,4,5)p3-dependent rac exchanger 1) (191 kDa, Complex from Homo sapiens)

EMD-23924

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Neurofibromin core

Release date: Dec. 15, 2021
Resolution: 4.56 Å
EM Method: Single-particle
Fitted PDBs: 7moc
Q-score: 0.278

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2021) 28 pp. 982-988 [ DOI: doi:10.1038/s41594-021-00687-2 Pubmed: 34887559 ]

Sample:

Neurofibromin (636 kDa, Complex from Homo sapiens)
Isoform i of neurofibromin (318 kDa, Protein from Homo sapiens)

EMD-23929

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Autoinhibited neurofibrobmin

Release date: Dec. 15, 2021
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7mp5
Q-score: 0.145

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2021) 28 pp. 982-988 [ DOI: doi:10.1038/s41594-021-00687-2 Pubmed: 34887559 ]

Sample:

Neurofibromin (636 kDa, Complex from Homo sapiens)
Isoform i of neurofibromin (318 kDa, Protein from Homo sapiens)

EMD-23930

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Neurofibromin homodimer

Release date: Dec. 15, 2021
Resolution: 6.25 Å
EM Method: Single-particle
Fitted PDBs: 7mp6
Q-score: 0.14

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2021) 28 pp. 982-988 [ DOI: doi:10.1038/s41594-021-00687-2 Pubmed: 34887559 ]

Sample:

Neurofibromin homodimer (630 kDa, Complex from Homo sapiens)
Isoform i of neurofibromin (318 kDa, Protein from Homo sapiens)

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