Human pro-meprin alpha (zymogen state)[subparticle localised reconstruction]
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7uab
Q-score: 0.36
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- Tetrameric portion of helical meprin alpha in the zymogen state (85 MDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Human pro-meprin alpha (zymogen state)[Focused classification and refinement]
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7uac
Q-score: 0.506
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- Single subunit of helical meprin alpha in the zymogen state (85 MDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Meprin alpha helix (activated) - full C1 consensus reconstruction
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- Full helical meprin alpha in the activated state (85 MDa, Complex from Homo sapiens)
- Human meprin alpha (Protein from Homo sapiens)
Human meprin alpha (active state)[subparticle localised reconstruction]
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7uae
Q-score: 0.553
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Single subunit of helical meprin alpha in the active state (85 MDa, Complex from Homo sapeins)
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7uaf
Q-score: 0.572
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- N~3~,n~3~-bis[(2h-1,3-benzodioxol-5-yl)methyl]-n-hydroxy-beta-alaninamide (372 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Tetrameric portion of helical meprin alpha in complex with a small molecule inhibitor (85 MDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Meprin alpha helix in complex with fetuin-B [consensus C1 reconstruction]
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7uai
Q-score: 0.425
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fetuin-b (42 kDa, Protein from Homo sapiens)
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Tetrameric portion of meprin alpha helix in complex with fetuin-b [subparticle localised reconstruction] (85 MDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Sub-tomogram average of pro-meprin alpha supercoiled filament
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]