Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7u23
Q-score: 0.188
Moreau F, Kirk NS, Zhang F, Gelfanov V, List EO, Chrudinova M, Venugopal H, Lawrence MC, Jimenez V, Bosch F, Kopchick JJ, DiMarchi RD, Altindis E, Ronald Kahn C
Nat Commun (2022) 13 pp. 6700-6700 [ Pubmed: 36335114 DOI: doi:10.1038/s41467-022-34391-6 ]
Human pro-meprin alpha (zymogen state)[subparticle localised reconstruction]
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7uab
Q-score: 0.36
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- Tetrameric portion of helical meprin alpha in the zymogen state (85 MDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Human pro-meprin alpha (zymogen state)[Focused classification and refinement]
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7uac
Q-score: 0.506
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- Single subunit of helical meprin alpha in the zymogen state (85 MDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Meprin alpha helix (activated) - full C1 consensus reconstruction
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- Full helical meprin alpha in the activated state (85 MDa, Complex from Homo sapiens)
- Human meprin alpha (Protein from Homo sapiens)
Human meprin alpha (active state)[subparticle localised reconstruction]
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7uae
Q-score: 0.553
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Single subunit of helical meprin alpha in the active state (85 MDa, Complex from Homo sapeins)
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7uaf
Q-score: 0.572
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- N~3~,n~3~-bis[(2h-1,3-benzodioxol-5-yl)methyl]-n-hydroxy-beta-alaninamide (372 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Tetrameric portion of helical meprin alpha in complex with a small molecule inhibitor (85 MDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Meprin alpha helix in complex with fetuin-B [consensus C1 reconstruction]
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7uai
Q-score: 0.425
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fetuin-b (42 kDa, Protein from Homo sapiens)
- Meprin a subunit alpha (67 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Tetrameric portion of meprin alpha helix in complex with fetuin-b [subparticle localised reconstruction] (85 MDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Sub-tomogram average of pro-meprin alpha supercoiled filament
Bayly-Jones C, Lupton CJ, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jager C, de Marco A, Schilling S, Schlenzig D, Whisstock JC
Nat Commun (2022) 13 pp. 6178-6178 [ Pubmed: 36261433 DOI: doi:10.1038/s41467-022-33893-7 ]
Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7lll
Q-score: 0.479
Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D
Nat Commun (2022) 13 pp. 92-92 [ Pubmed: 35013280 DOI: doi:10.1038/s41467-021-27760-0 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Exendin-4 (4 kDa, Protein from Heloderma suspectum)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Exendin-4-glp-1r-gs complex (Complex from Homo sapiens)