Chaetomium thermophilum SETX - NPPC internal deletion
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8fth
Q-score: 0.479
Appel CD, Bermek O, Dandey VP, Wood M, Viverette E, Williams JG, Bouvette J, Riccio AA, Krahn JM, Borgnia MJ, Williams RS
Mol Cell (2023) 83 pp. 3692- [ Pubmed: 37832548 DOI: doi:10.1016/j.molcel.2023.09.024 ]
Chaetomium thermophilum SETX (Full-length)
Resolution: 4.56 Å
EM Method: Single-particle
Fitted PDBs: 8ftk
Q-score: 0.288
Appel CD, Bermek O, Dandey VP, Wood M, Viverette E, Williams JG, Bouvette J, Riccio AA, Krahn JM, Borgnia MJ, Williams RS
Mol Cell (2023) 83 pp. 3692- [ Pubmed: 37832548 DOI: doi:10.1016/j.molcel.2023.09.024 ]
Appel CD, Bermek O, Dandey VP, Wood M, Viverette E, Williams JG, Bouvette J, Riccio AA, Krahn JM, Borgnia MJ, Williams RS
Mol Cell (2023) 83 pp. 3692-3706.e5 [ Pubmed: 37832548 DOI: doi:10.1016/j.molcel.2023.09.024 ]
Human tRNA Splicing Endonuclease Complex bound to 2'F-tRNA-Arg
Hayne CK, Butay KJU, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch RM, Deterding LJ, Matera AG, Borgnia MJ, Stanley RE
Nat Struct Mol Biol (2023) 30 pp. 824-833 [ DOI: doi:10.1038/s41594-023-00991-z Pubmed: 37231153 ]
Human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7uxa
Q-score: 0.472
Hayne CK, Butay KJU, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch RM, Deterding LJ, Matera AG, Borgnia MJ, Stanley RE
Nat Struct Mol Biol (2023) 30 pp. 824-833 [ DOI: doi:10.1038/s41594-023-00991-z Pubmed: 37231153 ]
- Trna-splicing endonuclease subunit sen34 (37 kDa, Protein from Homo sapiens)
- Trna-splicing endonuclease subunit sen2 (55 kDa, Protein from Homo sapiens)
- Trna-splicing endonuclease subunit sen15 (19 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Rna (78-mer) (28 kDa, RNA from synthetic construct)
- Trna-splicing endonuclease subunit sen54 (61 kDa, Protein from Homo sapiens)
- Human trna splicing endonuclease complex bound to pre-trna-arg (203 kDa, Complex from Homo sapiens)
Human Rix1 sub-complex scaffold
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7uwf
Q-score: 0.589
Gordon J, Chapus FL, Viverette EG, Williams JG, Deterding LJ, Krahn JM, Borgnia MJ, Rodriguez J, Warren AJ, Stanley RE
Nat Commun (2022) 13 pp. 6783-6783 [ DOI: doi:10.1038/s41467-022-34610-0 Pubmed: 36351913 ]
- Human rix1 sub-complex scaffold (236 MDa, Complex from Homo sapiens)
- Modulator of non-genomic activity of estrogen receptor (69 kDa, Protein from Homo sapiens)
- Wd repeat-containing protein 18 (49 kDa, Protein from Homo sapiens)
Octameric Human Twinkle Helicase Clinical Variant W315L
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7t8b
Q-score: 0.315
Riccio AA, Bouvette J, Perera L, Longley MJ, Krahn JM, Williams JG, Dutcher R, Borgnia MJ, Copeland WC
PNAS (2022) 119 pp. e2207459119-e2207459119 [ DOI: doi:10.1073/pnas.2207459119 Pubmed: 35914129 ]
- Twinkle mtdna helicase (78 kDa, Protein from Homo sapiens)
- Heptameric human twinkle clinical variant w315l (504 kDa, Complex from Homo sapiens)
Heptameric Human Twinkle Helicase Clinical Variant W315L
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7t8c
Q-score: 0.08
Riccio AA, Bouvette J, Perera L, Longley MJ, Krahn JM, Williams JG, Dutcher R, Borgnia MJ, Copeland WC
PNAS (2022) 119 pp. e2207459119-e2207459119 [ Pubmed: 35914129 DOI: doi:10.1073/pnas.2207459119 ]
- Twinkle mtdna helicase (78 kDa, Protein from Homo sapiens)
- Heptameric human twinkle clinical variant w315l (504 kDa, Complex from Homo sapiens)
Octameric Twinkle Helicase Clinical Variant W315L, local refinement
Riccio AA, Bouvette J, Perera L, Longley MJ, Krahn JM, Williams JG, Dutcher R, Borgnia MJ, Copeland WC
PNAS (2022) 119 pp. e2207459119-e2207459119 [ DOI: doi:10.1073/pnas.2207459119 Pubmed: 35914129 ]
CryoEM structure of the N-Terminal deleted Rix7 AAA-ATPase
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 7swl
Q-score: 0.546
Kocaman S, Lo YH, Krahn JM, Sobhany M, Dandey VP, Petrovich ML, Etigunta SK, Williams JG, Deterding LJ, Borgnia MJ, Stanley RE
Pnas Nexus (2022) 1 pp. pgac118-pgac118 [ DOI: doi:10.1093/pnasnexus/pgac118 Pubmed: 36090660 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cryoem structure of the n-terminal-deleted rix7 aaa-atpase (100 kDa, Complex from Chaetomium thermophilum)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Rix7 (69 kDa, Protein from Chaetomium thermophilum)
- Polyleucine (2 kDa, Protein from synthetic construct)