Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8szf
Q-score: 0.587
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
- Cinacalcet-bound active-state human calcium-sensing receptor casr dimer in lipid nanodiscs (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- Spermine (202 Da, Ligand)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8szg
Q-score: 0.491
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Spermine (202 Da, Ligand)
- Water (18 Da, Ligand)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Cinacalcet-bound human calcium-sensing receptor casr-gq complex in lipid nanodiscs (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8szh
Q-score: 0.572
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Spermine (202 Da, Ligand)
- Extracellular calcium-sensing receptor (99 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Water (18 Da, Ligand)
- Tryptophan (204 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Cinacalcet-bound human calcium-sensing receptor casr-gi complex in lipid nanodiscs (Complex from Homo sapiens)
Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8szi
Q-score: 0.51
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ Pubmed: 38326620 DOI: doi:10.1038/s41586-024-07055-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pam-free human calcium-sensing receptor casr-gi complex in lipid nanodiscs (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
- Extracellular calcium-sensing receptor (105 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Tryptophan (204 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
The structure of the PP2A-B56Delta holoenzyme mutant - E197K
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8u1x
Q-score: 0.556
Wu CG, Balakrishnan VK, Merrill RA, Parihar PS, Konovolov K, Chen YC, Xu Z, Wei H, Sundaresan R, Cui Q, Wadzinski BE, Swingle MR, Musiyenko A, Chung WK, Honkanen RE, Suzuki A, Huang X, Strack S, Xing Y
PNAS (2024) 121 pp. e2310727120-e2310727120 [ Pubmed: 38150499 DOI: doi:10.1073/pnas.2310727120 ]
- Manganese (ii) ion (54 Da, Ligand)
- Serine/threonine-protein phosphatase 2a 56 kda regulatory subunit delta isoform (70 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Protein phosphatase 2a b56 delta holoenzyme mutant - e197k (Complex from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
The structure of the PP2A-B56Delta holoenzyme mutant - E197K
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8u89
Q-score: 0.447
Wu CG, Balakrishnan VK, Merrill RA, Parihar PS, Konovolov K, Chen YC, Xu Z, Wei H, Sundaresan R, Cui Q, Wadzinski BE, Swingle MR, Musiyenko A, Chung WK, Honkanen RE, Suzuki A, Huang X, Strack S, Xing Y
PNAS (2024) 121 pp. e2310727120-e2310727120 [ DOI: doi:10.1073/pnas.2310727120 Pubmed: 38150499 ]
- Manganese (ii) ion (54 Da, Ligand)
- Serine/threonine-protein phosphatase 2a 56 kda regulatory subunit delta isoform (70 kDa, Protein from Homo sapiens)
- Protein phosphatase 2a b56 delta holoenzyme mutant - e197k (Complex from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7soy
Q-score: 0.319
Li Y, Balakrishnan VK, Rowse M, Wu CG, Bravos AP, Yadav VK, Ivarsson Y, Strack S, Novikova IV, Xing Y
eLife (2022) 11 [ Pubmed: 35924897 DOI: doi:10.7554/eLife.79736 ]
- The structure of pp2a-b56gamma holoenzyme-pme-1 complex (Complex from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
- Isoform gamma-1 of serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform (52 kDa, Protein from Homo sapiens)
- Protein phosphatase methylesterase 1 (42 kDa, Protein from Homo sapiens)