Cryo-EM structure of CD38 in complex with FTL004
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 8il3
Q-score: 0.387
Zhang G, Guo C, Wang Y, Zhang X, Liu S, Qu W, Chen C, Yan L, Yang Z, Zhang Z, Jiang X, Chen X, Liu H, Lai Q, Wei X, Lu Y, Zhao S, Deng H, Wang Y, Yu L, Yu H, Wu Y, Su Z, Chen P, Ren Z, Yu M, Qu F, Luo Y, Gou L, Li Q, Huang Y, Ma F, Yang J
J Hematol Oncol (2022) 15 pp. 177-177 [ Pubmed: 36581954 DOI: doi:10.1186/s13045-022-01395-0 ]
- Heavy chain (22 kDa, Protein from Homo sapiens)
- Adp-ribosyl cyclase/cyclic adp-ribose hydrolase 1 (26 kDa, Protein from Homo sapiens)
- Cryo-em structure of cd38 in complex with ftl004 (Complex from Homo sapiens)
- Light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8hix
Q-score: 0.489
Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F
Nat Commun (2023) 14 pp. 216-216 [ DOI: doi:10.1038/s41467-023-35882-w Pubmed: 36639690 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gpr21 and gs protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 21 (38 kDa, Protein from Homo sapiens)
- Nb35 (16 kDa, Protein from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8hj2
Q-score: 0.425
Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F
Nat Commun (2023) 14 pp. 216-216 [ DOI: doi:10.1038/s41467-023-35882-w Pubmed: 36639690 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (16 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 21 (39 kDa, Protein from Homo sapiens)
- Gpr21(wt) with g15 (Complex from Homo sapiens)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8hj0
Q-score: 0.466
Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F
Nat Commun (2023) 14 pp. 216-216 [ DOI: doi:10.1038/s41467-023-35882-w Pubmed: 36639690 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Gpr21 m5 with g15 (Complex from Homo sapiens)
- Probable g-protein coupled receptor 21 (38 kDa, Protein from Homo sapiens)
- Nb35 (16 kDa, Protein from Homo sapiens)
Orphan GPR20 in complex with Fab046
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8hs2
Q-score: 0.479
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F
Cell Discov (2023) 9 pp. 23-23 [ DOI: doi:10.1038/s41421-023-00520-8 Pubmed: 36849514 ]
- Soluble cytochrome b562,g-protein coupled receptor 20 (50 kDa, Protein from Homo sapiens)
- The complex of gpr20 with fab046 (Complex from Homo sapiens)
- Heavy chain of fab046 (26 kDa, Protein from Rattus)
- Light chain of fab046 (25 kDa, Protein from Rattus)
Gi bound orphan GPR20 in ligand-free state
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8hs3
Q-score: 0.483
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F
Cell Discov (2023) 9 pp. 23-23 [ DOI: doi:10.1038/s41421-023-00520-8 Pubmed: 36849514 ]
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Orphan gpr20 complex with gi trimer in the absence of a ligand (Complex from Homo sapiens)
- Ggama (8 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,g-protein coupled receptor 20 (56 kDa, Protein from Homo sapiens)
Gi bound Orphan GPR20 complex with Fab046 in ligand-free state
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8hsc
Q-score: 0.467
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F
Cell Discov (2023) 9 pp. 23-23 [ DOI: doi:10.1038/s41421-023-00520-8 Pubmed: 36849514 ]
- The complex of gi bound orphan gpr20 with fab046 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Vicugna pacos)
- Light chain of fab046 (25 kDa, Protein from Rattus)
- Soluble cytochrome b562,g-protein coupled receptor 20 (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Heavy chain of fab046 (25 kDa, Protein from Rattus)
Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xk2
Q-score: 0.471
Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ
Nat Commun (2023) 14 pp. 1692-1692 [ Pubmed: 36973264 DOI: doi:10.1038/s41467-023-37177-6 ]
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Niacin receptor hca2-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
SARS-CoV-2 S trimer in complex with 1F Fab
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7y7j
Q-score: 0.383
Zhao S, Liu F, Qiu S, Lan Q, Wu Y, Xu W, Ke J, Yang J, Liu X, Wang K, Guo H, Xia S, Zhang F, Wang J, Hu X, Lu L, Jiang S, Zhao S, Liu L, Xie Y, Yang X, Wang H, Zhong G
Protein Cell (2023) 14 pp. 74-78 [ DOI: doi:10.1093/procel/pwac042 Pubmed: 36726762 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 1f fab (Complex from Homo sapiens)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- 1f vl (11 kDa, Protein from Homo sapiens)
- 1f vh (14 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein complex with 1f fab (Complex)
SARS-CoV-2 RBD in complex with 1F Fab
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7y7k
Q-score: 0.241
Zhao S, Liu F, Qiu S, Lan Q, Wu Y, Xu W, Ke J, Yang J, Liu X, Wang K, Guo H, Xia S, Zhang F, Wang J, Hu X, Lu L, Jiang S, Zhao S, Liu L, Xie Y, Yang X, Wang H, Zhong G
Protein Cell (2023) 14 pp. 74-78 [ Pubmed: 36726762 DOI: doi:10.1093/procel/pwac042 ]
- Spike protein s1 (20 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 1f vl (11 kDa, Protein from Homo sapiens)
- 1f vh (14 kDa, Protein from Homo sapiens)
- 1f fab (Complex from Homo sapiens)
- Sars-cov-2 rbd complex with 1f fab (Complex)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)