Cryo-EM structure of a class T GPCR in active state
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 7xp6
Q-score: 0.415
Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T
Science (2022) 377 pp. 1298-1304 [ DOI: doi:10.1126/science.abo1633 Pubmed: 36108005 ]
- Nanobody 35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(t) subunit alpha-3 (30 kDa, Protein from Homo sapiens)
- Strychnine (334 Da, Ligand)
- Endoglucanase h,taste receptor type 2 member 46,endoglucanase h,taste receptor type 2 member 46,bitter taste receptor t2r46 (91 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Complex of gpcr and g protein (Complex from Homo sapiens)
Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 2E6 (CVB1-M:2E6)
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7x2o
Q-score: 0.591
Zheng Q, Zhu R, Yin Z, Xu L, Sun H, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y, Cheng T, Li S, Xia N
Cell Host Microbe (2022) 30 pp. 1279- [ DOI: doi:10.1016/j.chom.2022.08.001 Pubmed: 36002016 ]
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- 2e6 light chain (11 kDa, Protein from Mus musculus)
- Cryo-em structure of coxsackievirus b1 mature virion in complex with nab 2e6 (cvb1-m:2e6) (Complex from Coxsackievirus B1)
- Palmitic acid (256 Da, Ligand)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- 2e6 heavy chain (13 kDa, Protein from Mus musculus)
Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 8A10 (CVB1-M:8A10)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 7x2t
Q-score: 0.531
Zheng Q, Zhu R, Yin Z, Xu L, Sun H, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y, Cheng T, Li S, Xia N
Cell Host Microbe (2022) 30 pp. 1279- [ DOI: doi:10.1016/j.chom.2022.08.001 Pubmed: 36002016 ]
- Cryo-em structure of coxsackievirus b1 mature virion in complex with nab 8a10 (cvb1-m:8a10) (Complex from Coxsackievirus B1)
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- 8a10 heavy chain (13 kDa, Protein from Mus musculus)
- Palmitic acid (256 Da, Ligand)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- 8a10 light chain (11 kDa, Protein from Mus musculus)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 7x3c
Q-score: 0.607
Zheng Q, Zhu R, Yin Z, Xu L, Sun H, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y, Cheng T, Li S, Xia N
Cell Host Microbe (2022) 30 pp. 1279-1294.e6 [ DOI: doi:10.1016/j.chom.2022.08.001 Pubmed: 36002016 ]
- 5f5 light chain (11 kDa, Protein from Mus musculus)
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Cryo-em structure of coxsackievirus b1 muture virion in complex with nabs 8a10 and 5f5 (cvb1-m:8a10:5f5) (Complex from Coxsackievirus B1)
- 5f5 heavy chain (13 kDa, Protein from Mus musculus)
- 8a10 heavy chain (13 kDa, Protein from Mus musculus)
- Palmitic acid (256 Da, Ligand)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- 8a10 light chain (11 kDa, Protein from Mus musculus)
Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 9A3 (CVB1-M:9A3)
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 7x3d
Q-score: 0.538
Zheng Q, Zhu R, Yin Z, Xu L, Sun H, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y, Cheng T, Li S, Xia N
Cell Host Microbe (2022) 30 pp. 1279-1294.e6 [ Pubmed: 36002016 DOI: doi:10.1016/j.chom.2022.08.001 ]
- 9a3 light chain (11 kDa, Protein from Mus musculus)
- Cryo-em structure of coxsackievirus b1 mature virion in complex with nab 9a3 (cvb1-m:9a3) (Complex from Coxsackievirus B1)
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- 9a3 heavy chain (13 kDa, Protein from Mus musculus)
- Palmitic acid (256 Da, Ligand)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 7x40
Q-score: 0.612
Zheng Q, Zhu R, Yin Z, Xu L, Sun H, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y, Cheng T, Li S, Xia N
Cell Host Microbe (2022) 30 pp. 1279-1294.e6 [ DOI: doi:10.1016/j.chom.2022.08.001 Pubmed: 36002016 ]
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Cryo-em structure of coxsackievirus b1 mature virion in complex with nab 8a10 (classified from cvb1 mature virion in complex with 8a10 and 2e6) (Complex from Coxsackievirus B1)
- 8a10 heavy chain (13 kDa, Protein from Mus musculus)
- Palmitic acid (256 Da, Ligand)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- 8a10 light chain (11 kDa, Protein from Mus musculus)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7x49
Q-score: 0.597
Zheng Q, Zhu R, Yin Z, Xu L, Sun H, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y, Cheng T, Li S, Xia N
Cell Host Microbe (2022) 30 pp. 1279-1294.e6 [ Pubmed: 36002016 DOI: doi:10.1016/j.chom.2022.08.001 ]
- 8a10 light chain (11 kDa, Protein from Mus musculus)
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
- 8a10 heavy chain (13 kDa, Protein from Mus musculus)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- Palmitic acid (256 Da, Ligand)
- Cryo-em structure of coxsackievirus b1 mature virion in complex with nab 8a10 (classified from cvb1 mature virion in complex with 8a10 and 9a3) (Complex from Coxsackievirus B1)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7x4m
Q-score: 0.562
Zheng Q, Zhu R, Yin Z, Xu L, Sun H, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y, Cheng T, Li S, Xia N
Cell Host Microbe (2022) 30 pp. 1279-1294.e6 [ Pubmed: 36002016 DOI: doi:10.1016/j.chom.2022.08.001 ]
- 8a10 light chain (11 kDa, Protein from Mus musculus)
- Cryo-em structure of coxsackievirus b1 mature virion in complex with nab 8a10 (classified from cvb1 mature virion in complex with 8a10, 2e6 and 9a3) (Complex from Coxsackievirus B1)
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
- 8a10 heavy chain (13 kDa, Protein from Mus musculus)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- Palmitic acid (256 Da, Ligand)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
Cryo-EM structure of SARS-CoV-2 spike protein in complex with three nAbs X01, X10 and X17
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 7x7t
Q-score: 0.504
Xiong H, Sun H, Wang S, Yuan L, Liu L, Zhu Y, Zhang J, Huang Y, Qi R, Jiang Y, Ma J, Zhou M, Ma Y, Fu R, Yan S, Yue M, Wu Y, Wei M, Wang Y, Li T, Wang Y, Zheng Z, Yu H, Cheng T, Li S, Yuan Q, Zhang J, Guan Y, Zheng Q, Zhang T, Xia N
PNAS (2022) 119 pp. e2204256119-e2204256119 [ DOI: doi:10.1073/pnas.2204256119 Pubmed: 35972965 ]
- X10 light chain (12 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- X17 heavy chain (13 kDa, Protein from Mus musculus)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- X01 heavy chain (13 kDa, Protein from Mus musculus)
- X10 heavy chain (13 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 spike protein in complex with three nabs x01, x10 and x17 (Complex)
- Nabs x01, x10 and x17 (Complex from Mus musculus)
- X17 light chain (11 kDa, Protein from Mus musculus)
- X01 light chain (11 kDa, Protein from Mus musculus)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 7x7u
Q-score: 0.49
Xiong H, Sun H, Wang S, Yuan L, Liu L, Zhu Y, Zhang J, Huang Y, Qi R, Jiang Y, Ma J, Zhou M, Ma Y, Fu R, Yan S, Yue M, Wu Y, Wei M, Wang Y, Li T, Wang Y, Zheng Z, Yu H, Cheng T, Li S, Yuan Q, Zhang J, Guan Y, Zheng Q, Zhang T, Xia N
PNAS (2022) 119 pp. e2204256119-e2204256119 [ DOI: doi:10.1073/pnas.2204256119 Pubmed: 35972965 ]
- X10 light chain (12 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 delta variant spike protein in complex with three nabs x01, x10 and x17 (Complex)
- X17 heavy chain (13 kDa, Protein from Mus musculus)
- X01 heavy chain (13 kDa, Protein from Mus musculus)
- X10 heavy chain (13 kDa, Protein from Mus musculus)
- Nabs x01, x10 and x17 (Complex from Mus musculus)
- X17 light chain (11 kDa, Protein from Mus musculus)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- X01 light chain (11 kDa, Protein from Mus musculus)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)