Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8fvu
Q-score: 0.412
Matico RE, Yu X, Miller R, Somani S, Ricketts MD, Kumar N, Steele RA, Medley Q, Berger S, Faustin B, Sharma S
Nat Struct Mol Biol (2024) 31 pp. 82-91 [ DOI: doi:10.1038/s41594-023-01143-z Pubmed: 38177670 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Burkholderia needle (chimeric with an anthrax toxin lethal factor tag) (Complex from Bacillus anthracis)
- Human naip and nlrc4 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Lethal factor,type iii secretion system protein (42 kDa, Protein from Burkholderia)
- Nlr family card domain-containing protein 4 (116 kDa, Protein from Homo sapiens)
- The complex of needle, human naip and nlrc4 (Complex)
- Baculoviral iap repeat-containing protein 1 (160 kDa, Protein from Homo sapiens)
Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8fw2
Q-score: 0.331
Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 8fw9
Q-score: 0.24
Structure Of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8fu3
Q-score: 0.523
Yu X, Abeywickrema P, Bonneux B, Behera I, Anson B, Jacoby E, Fung A, Adhikary S, Bhaumik A, Carbajo RJ, De Bruyn S, Miller R, Patrick A, Pham Q, Piassek M, Verheyen N, Shareef A, Sutto-Ortiz P, Ysebaert N, Van Vlijmen H, Jonckers THM, Herschke F, McLellan JS, Decroly E, Fearns R, Grosse S, Roymans D, Sharma S, Rigaux P, Jin Z
Commun Biol (2023) 6 pp. 1074-1074 [ DOI: doi:10.1038/s42003-023-05451-4 Pubmed: 37865687 ]
- Rna-directed rna polymerase l (254 kDa, Protein from Human respiratory syncytial virus A2)
- 8-methoxy-3-methyl-n-{(2s)-3,3,3-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-hydroxypropyl}cinnoline-6-carboxamide (576 Da, Ligand)
- Structure of respiratory syncytial virus polymerase with novel non-nucleoside inhibitor (Complex from Human respiratory syncytial virus A2)
- Phosphoprotein (29 kDa, Protein from Human respiratory syncytial virus A2)
Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7uja
Q-score: 0.492
Che Y, Gribenko AV, Song X, Handke LD, Efferen KS, Tompkins K, Kodali S, Nunez L, Prasad AK, Phelan LM, Ammirati M, Yu X, Lees JA, Chen W, Martinez L, Roopchand V, Han S, Qiu X, DeVincenzo JP, Jansen KU, Dormitzer PR, Swanson KA
Sci Transl Med (2023) 15 pp. eade6422-eade6422 [ DOI: doi:10.1126/scitranslmed.ade6422 Pubmed: 37023209 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rsv variant (construct pxcs847a) f1 (45 kDa, Protein from Respiratory syncytial virus)
- Am14 fab light chain (23 kDa, Protein from Mus musculus)
- Am22 fab light chain (23 kDa, Protein from Mus musculus)
- Am22 fab heavy chain (25 kDa, Protein from Mus musculus)
- Human respiratory syncytial virus f variant (construct pxcs847a) with fabs am14 and am22 (Complex from Respiratory syncytial virus)
- Rsv variant (construct pxcs847a) f2 (12 kDa, Protein from Respiratory syncytial virus)
- Am14 fab heavy chain (26 kDa, Protein from Mus musculus)
Structure of Covid Spike variant deltaN135 in fully closed form
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8fu7
Q-score: 0.437
Yu X, Juraszek J, Rutten L, Bakkers MJG, Blokland S, Melchers JM, van den Broek NJF, Verwilligen AYW, Abeywickrema P, Vingerhoets J, Neefs JM, Bakhash SAM, Roychoudhury P, Greninger A, Sharma S, Langedijk JPM
PLoS Pathog (2023) 19 pp. e1011308-e1011308 [ DOI: doi:10.1371/journal.ppat.1011308 Pubmed: 37126534 ]
Structure of Covid Spike variant deltaN135 with one erect RBD
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8fu8
Q-score: 0.457
Yu X, Juraszek J, Rutten L, Bakkers MJG, Blokland S, Melchers JM, van den Broek NJF, Verwilligen AYW, Abeywickrema P, Vingerhoets J, Neefs JM, Bakhash SAM, Roychoudhury P, Greninger A, Sharma S, Langedijk JPM
PLoS Pathog (2023) 19 pp. e1011308-e1011308 [ DOI: doi:10.1371/journal.ppat.1011308 Pubmed: 37126534 ]
Structure of Covid Spike variant deltaN25 with one erect RBD
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8fu9
Q-score: 0.365
Yu X, Juraszek J, Rutten L, Bakkers MJG, Blokland S, Melchers JM, van den Broek NJF, Verwilligen AYW, Abeywickrema P, Vingerhoets J, Neefs JM, Bakhash SAM, Roychoudhury P, Greninger A, Sharma S, Langedijk JPM
PLoS Pathog (2023) 19 pp. e1011308-e1011308 [ DOI: doi:10.1371/journal.ppat.1011308 Pubmed: 37126534 ]
Structure of the human frataxin-bound iron-sulfur cluster assembly complex
Fox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S
Nat Commun (2019) 10 pp. 2210-2210 [ DOI: doi:10.1038/s41467-019-09989-y Pubmed: 31101807 ]
Structure of the human frataxin-bound iron-sulfur cluster assembly complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6nzu
Q-score: 0.546
Fox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S
Nat Commun (2019) 10 pp. 2210-2210 [ DOI: doi:10.1038/s41467-019-09989-y Pubmed: 31101807 ]
- Frataxin, mitochondrial (14 kDa, Protein from Homo sapiens)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Iron-sulfur cluster assembly enzyme iscu, mitochondrial (13 kDa, Protein from Homo sapiens)
- Acyl carrier protein (8 kDa, Protein from Escherichia coli)
- Lyr motif-containing protein 4 (10 kDa, Protein from Homo sapiens)
- Cysteine desulfurase, mitochondrial (44 kDa, Protein from Homo sapiens)
- S-[2-({n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate (540 Da, Ligand)
- The human frataxin-bound iron-sulfur cluster assembly complex (186 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)