Structure of E6AP-E6 complex in Att1 state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8jrn
Q-score: 0.531
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
- Zinc ion (65 Da, Ligand)
Structure of E6AP-E6 complex in Att2 state
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8jro
Q-score: 0.492
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
- Zinc ion (65 Da, Ligand)
Structure of E6AP-E6 complex in Att3 state
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8jrp
Q-score: 0.34
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Protein e6 (17 kDa, Protein from Human papillomavirus 16)
- E6ap-e6 complex (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of E6AP-E6 complex in Det1 state
Resolution: 4.15 Å
EM Method: Single-particle
Fitted PDBs: 8jrq
Q-score: 0.186
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
- Zinc ion (65 Da, Ligand)
Structure of E6AP-E6 complex in Det2 state
Resolution: 4.35 Å
EM Method: Single-particle
Fitted PDBs: 8jrr
Q-score: 0.164
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (16 kDa, Protein from Human papillomavirus 16)
Structure of human full-length E6AP
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- E6ap (Complex from Homo sapiens)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
Cryo-EM structure of NLRP3 open octamer
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8swf
Q-score: 0.31
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024) [ ]
- Nlrp3 open octamer complex (Complex from Homo sapiens)
- Nacht, lrr and pyd domains-containing protein 3 (103 kDa, Protein from Homo sapiens)
Cryo-EM structure of NLRP3 closed hexamer
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 8swk
Q-score: 0.24
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024) [ ]
- 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea (402 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Nlrp3 open octamer complex (Complex from Homo sapiens)
- Nacht, lrr and pyd domains-containing protein 3 (103 kDa, Protein from Homo sapiens)
Structure of NLRP3 and NEK7 complex
Resolution: 4.04 Å
EM Method: Single-particle
Fitted PDBs: 8sxn
Q-score: 0.33
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024) [ ]
- Covid spike variant deltan135 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea (402 Da, Ligand)
- Serine/threonine-protein kinase nek7 (34 kDa, Protein from Homo sapiens)
- Nacht, lrr and pyd domains-containing protein 3 (103 kDa, Protein from Homo sapiens)
CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8jgb
Q-score: 0.551
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the bam8-22-bound mrgprx1-gq complex (Complex from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Conorfamide-tx2 (2 kDa, Protein from Conus textile)