Cryo-EM structure of the SEP363856-bound mTAAR1-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8wc3
Q-score: 0.536
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- Cryo-em structure of the sep363856-bound mtaar1-gs complex (Complex from Homo sapiens)
- Trace amine-associated receptor 1 (37 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the ZH8651-bound mTAAR1-Gs complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8wc4
Q-score: 0.542
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- 2-(4-bromophenyl)ethanamine (200 Da, Ligand)
- Cryo-em structure of the zh8651-bound mtaar1-gs complex (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 1 (37 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the TMA-bound mTAAR1-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8wc5
Q-score: 0.5
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- Tetramethylammonium ion (74 Da, Ligand)
- Trace amine-associated receptor 1 (37 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the tma-bound mtaar1-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PEA-bound mTAAR1-Gs complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wc6
Q-score: 0.542
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- 2-phenylethylamine (122 Da, Ligand)
- Cryo-em structure of the pea-bound mtaar1-gs complex (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 1 (37 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the ZH8667-bound mTAAR1-Gs complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8wc7
Q-score: 0.538
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- Cryo-em structure of the zh8667-bound mtaar1-gs complex (Complex from Homo sapiens)
- 2-[4-(3-fluorophenyl)phenyl]ethanamine (215 Da, Ligand)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 1 (37 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8wc8
Q-score: 0.533
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- 2-(4-bromophenyl)ethanamine (200 Da, Ligand)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
- Cryo-em structure of the zh8651-bound htaar1-gs complex (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the ZH8651-bound mTAAR1-Gq complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wc9
Q-score: 0.516
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- 2-(4-bromophenyl)ethanamine (200 Da, Ligand)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Cryo-em structure of the zh8651-bound mtaar1-gq complex (Complex from Homo sapiens)
- Engineered g-alpha-q subunit (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 1 (37 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PEA-bound hTAAR1-Gs complex
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8wca
Q-score: 0.484
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- 2-phenylethylamine (122 Da, Ligand)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
- Cryo-em structure of the pea-bound htaar1-gs complex (Complex from Homo sapiens)
Cryo-EM structure of the CHA-bound mTAAR1-Gq complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8wcb
Q-score: 0.457
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- Cryo-em structure of the cha-bound mtaar1-gq complex (Complex from Homo sapiens)
- Engineered g-alpha-q subunit (41 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 1 (37 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cyclohexylammonium ion (100 Da, Ligand)
Cryo-EM structure of the CHA-bound mTAAR1 complex
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8wcc
Q-score: 0.48
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- Trace amine-associated receptor 1 (37 kDa, Protein from Mus musculus)
- Cryo-em structure of the cha-bound mtaar1 complex (Complex from Mus musculus)
- Cyclohexylammonium ion (100 Da, Ligand)