Identification, structure and agonist design of an androgen membrane receptor.
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gs protein alpha subunit (41 kDa, Protein from Bos taurus)
- Complex of gpr133 with agonist and g protein trime (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
Identification, structure and agonist design of an androgen membrane receptor
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Scfv16 (28 kDa, Protein from synthetic construct)
- Methyl 3-[2-(2,4-dimethylphenoxy)ethanoylamino]-4-(4-ethylpiperazin-1-yl)benzoate (425 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gs protein alpha subunit (41 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Complex of gpr133 with agonist and g protein trimer (Complex from Bos taurus)
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
Identification, structure and agonist design of an androgen membrane receptor
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- (5s,8r,9s,10s,13s,14s,17s)-17-hydroxy-1,10,13-trimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one (302 Da, Ligand)
- Scfv16 (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Complex of gpr133 with agonist and g protein trimer. (Complex from Rattus norvegicus)
- Gs protein alpha subunit (41 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
Identification, structure and agonist design of an androgen membrane receptor.
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from synthetic construct)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor d1 (34 kDa, Protein from Homo sapiens)
- Complex of gpr133 with agonist and g protein trime (Complex from Homo sapiens)
Identification, structure and agonist design of an androgen membrane receptor.
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Gs protein alpha subunit (41 kDa, Protein from Homo sapiens)
- Complex of gpr133 with agonist and g protein trime (Complex from Homo sapiens)
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
Cryo-EM structure of the C16:0 ceramide-bound FPR2-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8y62
Q-score: 0.491
Sun JP, Jiang CT, Kong W, Yu X, Cai K, Guo LL
To Be Published
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- N-formyl peptide receptor 2 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Cryo-em structure of the c16:0 ceramide-bound fpr2-gi complex (Complex from Homo sapiens)
- N-((e,2s,3r)-1,3-dihydroxyoctadec-4-en-2-yl)palmitamide (537 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
Cryo-EM structure of the C20:0 ceramide-bound FPR2-Gi complex
Sun JP, Jiang CT, Kong W, Yu X, Cai K, Guo LL
To Be Published
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cer(d18:0/20:0) (596 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the c20:0 ceramide-bound fpr2-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- N-formyl peptide receptor 2 (38 kDa, Protein from Homo sapiens)
EM map Of Respiratory Syncytial Virus Polymerase in complex with JNJ-2729
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 9c7y
Q-score: 0.502
Tran MT, Grosse S, Carbajo RJ, Jacoby E, Yin Y, Yu X, Martinez C, Stoops B, Cooymans L, Hu L, Lutter FH, Pieters S, Tan E, Alcazar J, Roymans D, van Vlijmen H, Rigaux P, Sharma S, Jonckers THM
Acs Med.Chem.Lett. (2024) 15 pp. 1549-1558 [ Pubmed: 39291020 DOI: doi:10.1021/acsmedchemlett.4c00272 ]
- Respiratory syncytial virus polymerase in complex with non-nucleoside inhibitor (Complex from Human respiratory syncytial virus A2)
- (2s)-1,1,1-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-3-[(4m)-4-(8-methoxyquinolin-6-yl)-1h-1,2,3-triazol-1-yl]propan-2-ol (585 Da, Ligand)
- Phosphoprotein (29 kDa, Protein from Human respiratory syncytial virus A2)
- Rna-directed rna polymerase l (254 kDa, Protein from Human respiratory syncytial virus A2)
Cryo-EM structure of prefusion-stabilized influenza B hemagglutinin
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8uad
Q-score: 0.598
Juraszek J, Milder FJ, Yu X, Blokland S, van Overveld D, Abeywickrema P, Tamara S, Sharma S, Rutten L, Bakkers MJG, Langedijk JPM
Pnas Nexus (2024) 3 pp. pgae462-pgae462 [ DOI: doi:10.1093/pnasnexus/pgae462 Pubmed: 39445049 ]
- Hemagglutinin ha1 chain (38 kDa, Protein from Influenza B virus)
- Hemagglutinin ha2 chain (19 kDa, Protein from Influenza B virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Prefusion-stabilized influenza b hemagglutinin (Complex from Influenza B virus)
Prefusion-stabilized trimer of FluB-HA under low pH conditions
Juraszek J, Milder FJ, Yu X, Blokland S, van Overveld D, Abeywickrema P, Tamara S, Sharma S, Rutten L, Bakkers MJG, Langedijk JPM
Pnas Nexus (2024) 3 pp. pgae462-pgae462 [ DOI: doi:10.1093/pnasnexus/pgae462 Pubmed: 39445049 ]