Cryo-EM structure of HmAb64 scFv in complex with CNE40 SOSIP trimer
Wang S, Chan KW, Wei D, Ma X, Liu S, Hu G, Park S, Pan R, Gu Y, Nazzari AF, Olia AS, Xu K, Lin BC, Louder MK, McKee K, Doria-Rose NA, Montefiori D, Seaman MS, Zhou T, Kwong PD, Arthos J, Kong XP, Lu S
Nat Commun (2024) 15 pp. 4301-4301 [ Pubmed: 38773089 DOI: doi:10.1038/s41467-024-48514-8 ]
- Hmab64 fv light chain (11 kDa, Protein from Homo sapiens)
- Hmab64 fv (Complex from Homo sapiens)
- Cne40 sosip trimer (Complex from Human immunodeficiency virus 1)
- 3d structure of hmab64 fv in complex with cne40 sosip trimer (Complex)
- Hmab64 fv heavy chain (13 kDa, Protein from Homo sapiens)
- Cne40 sosip transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cne40 sosip envelope glycoprotein gp120 (55 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819-833.e7 [ Pubmed: 33789084 DOI: 10.1016/j.chom.2021.03.005 ]
Image sets:
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819-833.e7 [ Pubmed: 33789084 DOI: 10.1016/j.chom.2021.03.005 ]
Image sets:
Banach BB, Cerutti G, Fahad AS, Shen CH, Oliveira De Souza M, Katsamba PS, Tsybovsky Y, Wang P, Nair MS, Huang Y, Francino-Urdániz IM, Steiner PJ, Gutiérrez-González M, Liu L, López Acevedo SN, Nazzari AF, Wolfe JR, Luo Y, Olia AS, Teng IT, Yu J, Zhou T, Reddem ER, Bimela J, Pan X, Madan B, Laflin AD, Nimrania R, Yuen KY, Whitehead TA, Ho DD, Kwong PD, Shapiro L, DeKosky BJ
Cell Rep (2021) 37 [ Pubmed: 34587480 DOI: 10.1016/j.celrep.2021.109771 ]
Image sets:
Banach BB, Cerutti G, Fahad AS, Shen CH, Oliveira De Souza M, Katsamba PS, Tsybovsky Y, Wang P, Nair MS, Huang Y, Francino-Urdániz IM, Steiner PJ, Gutiérrez-González M, Liu L, López Acevedo SN, Nazzari AF, Wolfe JR, Luo Y, Olia AS, Teng IT, Yu J, Zhou T, Reddem ER, Bimela J, Pan X, Madan B, Laflin AD, Nimrania R, Yuen KY, Whitehead TA, Ho DD, Kwong PD, Shapiro L, DeKosky BJ
Cell Rep (2021) 37 [ Pubmed: 34587480 DOI: 10.1016/j.celrep.2021.109771 ]
Image sets:
Cryo-EM structure of PCSK9 mimic HIT01-K21Q-R218E with AMG145 Fab
Zhang B, Chuang GY, Biju A, Biner D, Cheng J, Wang Y, Bao S, Chao CW, Lei H, Liu T, Nazzari AF, Yang Y, Zhou T, Chen SJ, Chen X, Kong WP, Ou L, Parchment DK, Sarfo EK, SiMa H, Todd JP, Wang S, Woodward RA, Cheng C, Rawi R, Mascola JR, Kwong PD
Cell Rep (2024) 43 pp. 114285-114285 [ Pubmed: 38819987 DOI: doi:10.1016/j.celrep.2024.114285 ]
L5A7 Fab bound to Indonesia2005 Hemagglutinin
Olia AS, Prabhakaran M, Harris DR, Cheung CS, Gillespie RA, Gorman J, Hoover A, Morano NC, Ourahmane A, Srikanth A, Wang S, Wu W, Zhou T, Andrews SF, Kanekiyo M, Shapiro L, McDermott AB, Kwong PD
Front Immunol (2024) 15 pp. 1399960-1399960 [ Pubmed: 38873606 DOI: doi:10.3389/fimmu.2024.1399960 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of l5a7 fab and indonesia2005 ha (Complex from Homo sapiens)
- L5a7 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Hemagglutinin ha2 chain (19 kDa, Protein from Influenza A virus)
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus)
- L5a7 fab light chain (22 kDa, Protein from Homo sapiens)
L5A7 Fab bound to 28H6E11 anti-idiotype Fab
Olia AS, Prabhakaran M, Harris DR, Cheung CS, Gillespie RA, Gorman J, Hoover A, Morano NC, Ourahmane A, Srikanth A, Wang S, Wu W, Zhou T, Andrews SF, Kanekiyo M, Shapiro L, McDermott AB, Kwong PD
Front Immunol (2024) 15 pp. 1399960-1399960 [ Pubmed: 38873606 DOI: doi:10.3389/fimmu.2024.1399960 ]
- Complex of l5a7 fab and 28h6e11 fab (Complex from Homo sapiens)
- L5a7 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 28h6e11 fab heavy chain (23 kDa, Protein from Homo sapiens)
- L5a7 fab light chain (22 kDa, Protein from Homo sapiens)
- 28h6e11 fab light chain (24 kDa, Protein from Homo sapiens)
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8tng
Q-score: 0.402
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoproteihiv-1 bg505 ds-sosip gp41n gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Complex between hiv-1 env bg505 ds-sosip and llama nanobody r27 (252 kDa, Complex from Lama glama)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Cd4-binding site targeting nanobody r27 (12 kDa, Protein from Lama glama)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8tnh
Q-score: 0.43
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex between hiv-1 env bg505 ds-sosip and llama nanobody g36 (252 kDa, Complex from Lama glama)
- Cd4-binding site nanobody g36 (13 kDa, Protein from Lama glama)
- Hiv-1 bg505 ds-sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)