Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Zhang K" AND author_name:"Suomivuori CM" AND database:"EMDB" AND natural_source_ncbi_code:"10090"

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EMD-25762

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Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist

Release date: Aug. 10, 2022
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7t9m
Q-score: 0.396

Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A

Nature (2022) 609 pp. 846-853 [ Pubmed: 35940205 DOI: doi:10.1038/s41586-022-05159-1 ]

Sample:

2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human thyrotropin receptor in complex with the murine inverse agonist fab fragment cs-17 (Complex from Homo sapiens)
Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
Cs-17 light chain (23 kDa, Protein from Mus musculus)
Cs-17 heavy chain (23 kDa, Protein from Mus musculus)

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