Org 2274179-0-bound Thyrotropin Receptor
Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022) 609 pp. 846-853 [ Pubmed: 35940205 DOI: doi:10.1038/s41586-022-05159-1 ]
Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7t9m
Q-score: 0.396
Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022) 609 pp. 846-853 [ Pubmed: 35940205 DOI: doi:10.1038/s41586-022-05159-1 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human thyrotropin receptor in complex with the murine inverse agonist fab fragment cs-17 (Complex from Homo sapiens)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Cs-17 light chain (23 kDa, Protein from Mus musculus)
- Cs-17 heavy chain (23 kDa, Protein from Mus musculus)
Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7t9i
Q-score: 0.375
Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022) 609 pp. 846-853 [ Pubmed: 35940205 DOI: doi:10.1038/s41586-022-05159-1 ]
- Thyrotropin subunit beta (12 kDa, Protein from human)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure) (Complex from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain (10 kDa, Protein from human)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7t9n
Q-score: 0.495
Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022) 609 pp. 846-853 [ Pubmed: 35940205 DOI: doi:10.1038/s41586-022-05159-1 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- (2s)-3-hydroxypropane-1,2-diyl dihexadecanoate (568 Da, Ligand)
- M22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure) (Complex)
- M22 fab heavy chain (27 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- M22 fab light chain (25 kDa, Protein from Homo sapiens)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7utz
Q-score: 0.52
Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022) 609 pp. 846-853 [ Pubmed: 35940205 DOI: doi:10.1038/s41586-022-05159-1 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Homo sapiens)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain analog tr1402 (10 kDa, Protein from Homo sapiens)
- (2s)-3-hydroxypropane-1,2-diyl dihexadecanoate (568 Da, Ligand)
- Human tsh analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Thyrotropin subunit beta (12 kDa, Protein from Homo sapiens)
cryo-EM structure of MBP-KIX-apoferritin
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 7tb3
Q-score: 0.382
Zhang K, Horikoshi N, Li S, Powers AS, Hameedi MA, Pintilie GD, Chae HD, Khan YA, Suomivuori CM, Dror RO, Sakamoto KM, Chiu W, Wakatsuki S
ACS Cent Sci (2022) 8 pp. 214-222 [ Pubmed: 35233453 DOI: doi:10.1021/acscentsci.1c01090 ]
- Isoform 2 of creb-binding protein,ferritin heavy chain, n-terminally processed (30 kDa, Protein from Homo sapiens)
- Mbp-kix-apoferritin (1 MDa, Complex from Homo sapiens)
cryo-EM structure of MBP-KIX-apoferritin complex with peptide 7
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7tbh
Q-score: 0.361
Zhang K, Horikoshi N, Li S, Powers AS, Hameedi MA, Pintilie GD, Chae HD, Khan YA, Suomivuori CM, Dror RO, Sakamoto KM, Chiu W, Wakatsuki S
ACS Cent Sci (2022) 8 pp. 214-222 [ DOI: doi:10.1021/acscentsci.1c01090 Pubmed: 35233453 ]
- Mbp-kix-apoferritin complex with peptide 7 (1 MDa, Complex from Homo sapiens)
- Isoform 2 of creb-binding protein,ferritin heavy chain, n-terminally processed (30 kDa, Protein from Homo sapiens)
- Leu-ser-arg-arg-pro-sep-tyr-arg-lys-ile-leu-asn-asp-leu-ser-ser-asp-ala-pro (2 kDa, Protein from Homo sapiens)