Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with m7GpppAmU
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 8jce
Q-score: 0.643
Law MCY, Zhang K, Tan YB, Nguyen TM, Luo D
J Biol Chem (2023) 299 pp. 105415-105415 [ DOI: doi:10.1016/j.jbc.2023.105415 Pubmed: 37918803 ]
- Magnesium ion (24 Da, Ligand)
- [(2~{r},3~{r},4~{r},5~{r})-5-(6-azanyl-7,8-dihydropurin-9-yl)-2-[[[[[(2~{r},3~{s},4~{r},5~{r})-5-(2-azanyl-7-methyl-6-oxidanylidene-1,8-dihydropurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-4-methoxy-oxolan-3-yl] [(2~{r},3~{s},4~{r},5~{s})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (1 kDa, Ligand)
- Water (18 Da, Ligand)
- Mrna-capping enzyme nsp1 (61 kDa, Protein from Chikungunya virus strain S27-African prototype)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Nonstructural protein 1 (Complex from Chikungunya virus strain S27-African prototype)
Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with inhibitor FHA
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 7x01
Q-score: 0.599
Zhang K, Law MCY, Nguyen TM, Tan YB, Wirawan M, Law YS, Jeong LS, Luo D
Cell Rep (2022) 40 pp. 111133-111133 [ Pubmed: 35905713 DOI: doi:10.1016/j.celrep.2022.111133 ]
- Nonstructural protein 1 (Complex from Chikungunya virus strain S27-African prototype)
- Zinc ion (65 Da, Ligand)
- Mrna-capping enzyme nsp1 (62 kDa, Protein from Chikungunya virus strain S27-African prototype)
- (1r,2s,3s,4r,5r)-3-(6-aminopurin-9-yl)-4-fluoranyl-5-(2-hydroxyethyl)cyclopentane-1,2-diol (297 Da, Ligand)
Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with m7GTP
Resolution: 2.19 Å
EM Method: Single-particle
Fitted PDBs: 7fgg
Q-score: 0.698
Zhang K, Law MCY, Nguyen TM, Tan YB, Wirawan M, Law YS, Jeong LS, Luo D
Cell Rep (2022) 40 pp. 111133-111133 [ Pubmed: 35905713 DOI: doi:10.1016/j.celrep.2022.111133 ]
- Nonstructural protein 1 (Complex from Chikungunya virus strain S27-African prototype)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Water (18 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 7-methyl-guanosine-5'-triphosphate (538 Da, Ligand)
- Mrna-capping enzyme nsp1 (62 kDa, Protein from Chikungunya virus strain S27-African prototype)
Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with m7GMP
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 7fgh
Q-score: 0.688
Zhang K, Law MCY, Nguyen TM, Tan YB, Wirawan M, Law YS, Jeong LS, Luo D
Cell Rep (2022) 40 pp. 111133-111133 [ Pubmed: 35905713 DOI: doi:10.1016/j.celrep.2022.111133 ]
- Nonstructural protein 1 (Complex from Chikungunya virus strain S27-African prototype)
- N7-methyl-guanosine-5'-monophosphate (378 Da, Ligand)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Mrna-capping enzyme nsp1 (62 kDa, Protein from Chikungunya virus strain S27-African prototype)
Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with m7Gppp-AU
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 7fgi
Q-score: 0.627
Zhang K, Law MCY, Nguyen TM, Tan YB, Wirawan M, Law YS, Jeong LS, Luo D
Cell Rep (2022) 40 pp. 111133-111133 [ DOI: doi:10.1016/j.celrep.2022.111133 Pubmed: 35905713 ]
- Magnesium ion (24 Da, Ligand)
- Mrna-capping enzyme nsp1 (61 kDa, Protein from Chikungunya virus strain S27-African prototype)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- M7gppp-au (1 kDa, RNA from synthetic construct)
- Nonstructural protein 1 (Complex from Chikungunya virus strain S27-African prototype)