Cryo-EM structure of unliganded full-length TRPV1 at neutral pH
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 7l2h
Q-score: 0.521
Cell (2021) 184 pp. 5138- [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
- (2s)-1-(butanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3s,4s,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate (600 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- (10r,13s)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl tridecanoate (523 Da, Ligand)
- Full-length trpv1 in nanodisc (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 1 (95 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of full-length TRPV1 at pH6a state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7l2i
Q-score: 0.409
Cell (2021) 184 pp. 5138- [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
- Full-length trpv1 in nanodisc at ph6a state (Complex from Rattus norvegicus)
- (2s)-1-(butanoyloxy)-3-{[(r)-hydroxy{[(1s,2r,3r,4r,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate (600 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (95 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of full-length TRPV1 at pH6c state
Resolution: 3.66 Å
EM Method: Single-particle
Fitted PDBs: 7l2j
Q-score: 0.395
Cell (2021) 184 pp. 5138- [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
- (2s)-1-(butanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3s,4s,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate (600 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (95 kDa, Protein from Rattus norvegicus)
- Full-length trpv1 in nanodisc (Complex from Rattus norvegicus)
Cryo-EM structure of RTX-bound full-length TRPV1 in O1 state
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7l2l
Q-score: 0.414
Cell (2021) 184 pp. 5138- [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
Cryo-EM structure of DkTx/RTX-bound full-length TRPV1
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 7l2m
Q-score: 0.399
Cell (2021) 184 pp. 5138- [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
- Full-length trpv1 in nanodisc (Complex)
- Sodium ion (22 Da, Ligand)
- Tau-theraphotoxin-hs1a (8 kDa, Protein from Cyriopagopus schmidti)
- Resiniferatoxin (628 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (95 kDa, Protein from Rattus norvegicus)
- Tau-theraphotoxin-hs1a (Complex from Cyriopagopus schmidtiCyriopagopus schmidti)
- Transient receptor potential cation channel subfamily v member 1 (Complex from Rattus norvegicus)
Cryo-EM structure of RTX-bound full-length TRPV1 in C1 state
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7l2n
Q-score: 0.451
Cell (2021) 184 pp. 5138- [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
Cryo-EM structure of RTX-bound full-length TRPV1 at pH 5.5
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 7l2o
Q-score: 0.393
Cell (2021) 184 pp. 5138- [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
cryo-EM structure of unliganded minimal TRPV1
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7l2p
Q-score: 0.528
Cell (2021) 184 pp. 5138-5150.e12 [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
- (10r,13s)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate (565 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (73 kDa, Protein from Rattus norvegicus)
- (2s)-1-(butanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3s,4s,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate (600 Da, Ligand)
- Minimal trpv1 in nanodisc (Complex from Rattus norvegicus)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7l2r
Q-score: 0.493
Cell (2021) 184 pp. 5138- [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
- (2s)-1-(butanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3s,4s,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate (600 Da, Ligand)
- Minimal trpv1 in nanodisc (Complex from Rattus norvegicus)
- Sodium ion (22 Da, Ligand)
- (9r,12r)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate (481 Da, Ligand)
- Tau-theraphotoxin-hs1a (8 kDa, Protein from Cyriopagopus schmidti)
- Transient receptor potential cation channel subfamily v member 1 (73 kDa, Protein from Rattus norvegicus)
- Water (18 Da, Ligand)
cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-bound state
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 7l2s
Q-score: 0.561
Cell (2021) 184 pp. 5138-5150.e12 [ DOI: doi:10.1016/j.cell.2021.08.012 Pubmed: 34496225 ]
- (10r,13s)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate (565 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (73 kDa, Protein from Rattus norvegicus)
- (2s)-1-(butanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3s,4s,5r,6s)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate (600 Da, Ligand)
- Minimal trpv1 in nanodisc (Complex from Rattus norvegicus)
- Sodium ion (22 Da, Ligand)