Electron Microscopy Data Bank

EMD-32822

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An apo TRiC map

Release date: Jan. 11, 2023
Resolution: 3.11 Å
EM Method: Single-particle

Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J

Cell (2022) 185 pp. 4770-4787.e20 [ Pubmed: 36493755 DOI: doi:10.1016/j.cell.2022.11.014 ]

Sample:

Cct subunit 5 (Macromolecule from Homo sapiens)
Cct subunit 7 (Macromolecule from Homo sapiens)
Cct subunit 4 (Macromolecule from Homo sapiens)
Cct subunit 6 (Macromolecule from Homo sapiens)
Cct subunit 2 (Macromolecule from Homo sapiens)
Cct subunit 8 (Macromolecule from Homo sapiens)
Apo tric/cct (1 MDa, Complex from Homo sapiens)
Cct subunit 1 (Macromolecule from Homo sapiens)
Cct subunit 3 (Macromolecule from Homo sapiens)

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EMD-26089

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The beta-tubulin folding intermediate I

Release date: Dec. 28, 2022
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7trg
Q-score: 0.549

Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J

Cell (2022) 185 pp. 4770-4787.e20 [ Pubmed: 36493755 DOI: doi:10.1016/j.cell.2022.11.014 ]

Sample:

Closed form human tric in complex with beta-tubulin under atp/alf3condition. (1 MDa, Complex from Homo sapiens)
T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
Tubulin beta chain (49 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
T-complex protein 1 subunit eta (60 kDa, Protein from Homo sapiens)
Aluminum fluoride (83 Da, Ligand)
Water (18 Da, Ligand)
T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)

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EMD-26120

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The beta-tubulin folding intermediate II

Release date: Dec. 28, 2022
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ttn
Q-score: 0.526

Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J

Cell (2022) 185 pp. 4770-4787.e20 [ Pubmed: 36493755 DOI: doi:10.1016/j.cell.2022.11.014 ]

Sample:

T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
Tubulin beta chain (49 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
Aluminum fluoride (83 Da, Ligand)
T-complex protein 1 subunit eta (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Adenosine-5'-diphosphate (427 Da, Ligand)
Water (18 Da, Ligand)
Closed form human tric in complex with beta-tubulin under atp/alfx condition. (1 MDa, Complex from Homo sapiens)
T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)

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EMD-26123

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The beta-tubulin folding intermediate III

Release date: Dec. 28, 2022
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7ttt
Q-score: 0.561

Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J

Cell (2022) 185 pp. 4770-4787.e20 [ Pubmed: 36493755 DOI: doi:10.1016/j.cell.2022.11.014 ]

Sample:

T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta (60 kDa, Protein from Homo sapiens)
Closed form human tric in complex with beta-tubulin under atp/alfx condition. (1 MDa, Complex from Homo sapiens)
T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Water (18 Da, Ligand)
Magnesium ion (24 Da, Ligand)
T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
Tubulin beta chain (49 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
Aluminum fluoride (83 Da, Ligand)
T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)

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EMD-26131

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The beta-tubulin folding intermediate IV

Release date: Dec. 28, 2022
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7tub
Q-score: 0.5

Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J

Cell (2022) 185 pp. 4770-4787.e20 [ Pubmed: 36493755 DOI: doi:10.1016/j.cell.2022.11.014 ]

Sample:

T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta (60 kDa, Protein from Homo sapiens)
Closed form human tric in complex with beta-tubulin under atp/alfx condition. (1 MDa, Complex from Homo sapiens)
T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Water (18 Da, Ligand)
Magnesium ion (24 Da, Ligand)
T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
Tubulin beta chain (49 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
Aluminum fluoride (83 Da, Ligand)
T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)

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EMD-32823

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Prefoldin-tubulin-TRiC complex

Release date: Dec. 21, 2022
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7wu7
Q-score: 0.302

Gestaut D, Zhao Y, Park J, Ma B, Leitner A, Collier M, Pintilie G, Roh SH, Chiu W, Frydman J

Cell (2022) 185 pp. 4770-4787.e20 [ DOI: doi:10.1016/j.cell.2022.11.014 Pubmed: 36493755 ]

Sample:

Prefoldin subunit 1 (14 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
Prefoldin subunit 5 (16 kDa, Protein from Homo sapiens)
Prefoldin subunit 2 (16 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Prefoldin subunit 4 (16 kDa, Protein from Homo sapiens)
Prefoldin subunit 6 (14 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
Ternary complex of tric/cct, beta-tubulin, prefoldin complex (1 MDa, Complex from Homo sapiens)
T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
Prefoldin subunit 3 (22 kDa, Protein from Homo sapiens)

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EMPIAR-10770

Release date: Jan. 21, 2022
Dataset size: 48.4 GB
Experiment type: EMDB

Zhao Y, Schmid MF, Frydman J, Chiu W

Nat Commun (2021) 12 [ Pubmed: 34362932 DOI: 10.1038/s41467-021-25099-0 ]

Image sets:

aligned particle image

EMD-24324

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Methanococcus maripaludis chaperonin, open conformation 1

Release date: Aug. 11, 2021
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7r9e
Q-score: 0.233

Zhao Y, Schmid MF, Frydman J, Chiu W

Nat Commun (2021) 12 pp. 4754-4754 [ DOI: doi:10.1038/s41467-021-25099-0 Pubmed: 34362932 ]

Sample:

Chaperonin (54 kDa, Protein from Methanococcus maripaludis)
Mmcpn (1 MDa, Complex from Methanococcus maripaludis)

EMD-24325

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Methanococcus maripaludis chaperonin, open conformation 2

Release date: Aug. 11, 2021
Resolution: 6.3 Å
EM Method: Single-particle
Fitted PDBs: 7r9h
Q-score: 0.184

Zhao Y, Schmid MF, Frydman J, Chiu W

Nat Commun (2021) 12 pp. 4754-4754 [ DOI: doi:10.1038/s41467-021-25099-0 Pubmed: 34362932 ]

Sample:

Chaperonin (54 kDa, Protein from Methanococcus maripaludis)
Mmcpn (1 MDa, Complex from Methanococcus maripaludis)

EMD-24326

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Methanococcus maripaludis chaperonin, open conformation 2

Release date: Aug. 11, 2021
Resolution: 6.4 Å
EM Method: Single-particle
Fitted PDBs: 7r9i
Q-score: 0.167

Zhao Y, Schmid MF, Frydman J, Chiu W

Nat Commun (2021) 12 pp. 4754-4754 [ DOI: doi:10.1038/s41467-021-25099-0 Pubmed: 34362932 ]

Sample:

Mmcpn (1 MDa, Complex from Methanococcus maripaludis)
Chaperonin (54 kDa, Protein from Methanococcus maripaludis)

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