Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 7yoy
Q-score: 0.464
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med (2023) 4 pp. 101296-101296 [ Pubmed: 37992686 DOI: doi:10.1016/j.xcrm.2023.101296 ]
- 3e8 heavy chain (12 kDa, Protein from Oryctolagus cuniculus)
- 3e8 light chain (11 kDa, Protein from Oryctolagus cuniculus)
- 5e3,3e8 (Complex from Oryctolagus cuniculus)
- Gp42 (Complex from Human gammaherpesvirus 4)
- Ebv ghgl-gp42 in complex with mabs 3e8 and 5e3 (Complex)
- Soluble gp42 (15 kDa, Protein from Human gammaherpesvirus 4)
- 5e3 light chain (11 kDa, Protein from Oryctolagus cuniculus)
- 5e3 heavy chain (13 kDa, Protein from Oryctolagus cuniculus)
Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 10E4 (localized refinement)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7yp1
Q-score: 0.523
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med (2023) 4 pp. 101296-101296 [ Pubmed: 37992686 DOI: doi:10.1016/j.xcrm.2023.101296 ]
- Gh,gl (Complex from Human gammaherpesvirus 4)
- Ebv gl (8 kDa, Protein from Human gammaherpesvirus 4)
- Ebv gh (22 kDa, Protein from Human gammaherpesvirus 4)
- 10e4 (Complex from Oryctolagus cuniculus)
- 10e4 heavy chain (12 kDa, Protein from Oryctolagus cuniculus)
- 10e4 light chain (11 kDa, Protein from Oryctolagus cuniculus)
- Ghgl-gp42 in complex with mab 10e4 (Complex)
Cryo-EM density map of EBV gHgL-gp42 in complex with four mAbs 5E3, 3E8, 6H2 and 10E4
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med (2023) 4 pp. 101296-101296 [ Pubmed: 37992686 DOI: doi:10.1016/j.xcrm.2023.101296 ]
Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 6H2 (localized refinement)
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 7yp2
Q-score: 0.53
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med (2023) 4 pp. 101296-101296 [ Pubmed: 37992686 DOI: doi:10.1016/j.xcrm.2023.101296 ]
- 6h2 (Complex from Mus musculus)
- Envelope glycoprotein h (34 kDa, Protein from Human gammaherpesvirus 4)
- Gh (Complex from Human gammaherpesvirus 4)
- 6h2 light chain (12 kDa, Protein from Mus musculus)
- 6h2 heavy chain (13 kDa, Protein from Mus musculus)
- Ebv ghgl-gp42 in complex with mab 6h2 (Complex)
Computational design of a potent Epstein-Barr virus fusion protein gB nanoparticle vaccine
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7xni
Q-score: 0.315
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ Pubmed: 36763058 DOI: doi:10.1073/pnas.2207067119 ]
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- Kcnq1-cam complex (Cellular component from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
human KCNQ1-CaM in complex with ML277
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7xnk
Q-score: 0.467
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ Pubmed: 36763058 DOI: doi:10.1073/pnas.2207067119 ]
- Potassium ion (39 Da, Ligand)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
- Kcnq1-cam in complex with ml277 (Cellular component from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
human KCNQ1-CaM-ML277-PIP2 complex in state A
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xnl
Q-score: 0.412
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ Pubmed: 36763058 DOI: doi:10.1073/pnas.2207067119 ]
- Human kcnq1-cam-ml277-pip2 complex in state a (Cellular component from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
human KCNQ1-CaM-ML277-PIP2 complex in state B
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7xnn
Q-score: 0.428
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ Pubmed: 36763058 DOI: doi:10.1073/pnas.2207067119 ]
- Human kcnq1-cam-ml277-pip2 complex in state b (Cellular component from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Computational design of a potent Epstein-Barr virus fusion protein gB nanoparticle vaccine