Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid"

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EMD-42101

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Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with CFTRinh-172 and ATP/Mg

Release date: Feb. 21, 2024
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ubr
Q-score: 0.61

Young PG, Levring J, Fiedorczuk K, Blanchard SC, Chen J

PNAS (2024) 121 pp. e2316675121-e2316675121 [ DOI: doi:10.1073/pnas.2316675121 Pubmed: 38422021 ]

Sample:

4-[(z)-{(3m)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid (409 Da, Ligand)
Adenosine-5'-triphosphate (507 Da, Ligand)
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
Water (18 Da, Ligand)
Cholesterol (386 Da, Ligand)
Complex of cftr with the small molecule inhibitor cftrinh-172 (168 kDa, Complex from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Cystic fibrosis transmembrane conductance regulator (168 kDa, Protein from Homo sapiens)

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