Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8pm6
Q-score: 0.428
Liu H, Irobalieva RN, Kowal J, Ni D, Nosol K, Bang-Sorensen R, Lancien L, Stahlberg H, Stieger B, Locher KP
Nat Commun (2023) 14 pp. 7296-7296 [ Pubmed: 37949847 DOI: doi:10.1038/s41467-023-43109-1 ]
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- The complex of bsep with inhibitor gbm (146 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Bile salt export pump (146 kDa, Protein from Homo sapiens)
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7u24
Q-score: 0.452
Sung MW, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL
J Mol Biol (2022) 434 pp. 167789-167789 [ Pubmed: 35964676 DOI: doi:10.1016/j.jmb.2022.167789 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sur1 (Complex from Rattus norvegicus)
- Phosphatidylethanolamine (734 Da, Ligand)
- Kir6.2 (Complex from Cricetus cricetus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Katp-gbc-atp-ctdup (Complex from Cricetus cricetus)
Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7mit
Q-score: 0.51
Sung MW, Yang Z, Driggers CM, Patton BL, Mostofian B, Russo JD, Zuckerman DM, Shyng SL
PNAS (2021) 118 [ Pubmed: 34711681 DOI: doi:10.1073/pnas.2109441118 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Vascular katp channel: kir6.1 sur2b propeller-like conformation 1 (889 kDa, Complex from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 8 (48 kDa, Protein from Rattus norvegicus)
Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 1
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7mjo
Q-score: 0.429
Sung MW, Yang Z, Driggers CM, Patton BL, Mostofian B, Russo JD, Zuckerman DM, Shyng SL
PNAS (2021) 118 [ Pubmed: 34711681 DOI: doi:10.1073/pnas.2109441118 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Vascular katp channel: kir6.1 sur2b quatrefoil-like conformation 2 (889 kDa, Complex from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 8 (48 kDa, Protein from Rattus norvegicus)
Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7mjp
Q-score: 0.382
Sung MW, Yang Z, Driggers CM, Patton BL, Mostofian B, Russo JD, Zuckerman DM, Shyng SL
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2109441118 Pubmed: 34711681 ]
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 8 (48 kDa, Protein from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Isoform sur2b of atp-binding cassette sub-family c member 9 (174 kDa, Protein from Rattus norvegicus)
- Vascular katp channel: kir6.1 sur2b propeller-like conformation 2 (889 kDa, Complex from Rattus norvegicus)
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to ATP and glibenclamide
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 6pza
Q-score: 0.26
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL
eLife (2019) 8 [ DOI: doi:10.7554/eLife.46417 Pubmed: 31343405 ]
- Kntp (Complex from Rattus norvegicus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Katp-rpg-atp (Complex)
- Atp-binding cassette sub-family c member 8 (177 kDa, Protein from Cricetus cricetus)
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Rattus norvegicus)
- Sur1 (Complex from Cricetus cricetus)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5yw7
Q-score: 0.305
Wu JX, Ding D, Wang M, Kang Y, Zeng X, Chen L
Protein Cell (2018) 9 pp. 553-567 [ DOI: doi:10.1007/s13238-018-0530-y Pubmed: 29594720 ]
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- Katp (Complex from Mesocricetus auratus)
Resolution: 4.11 Å
EM Method: Single-particle
Fitted PDBs: 5yke
Q-score: 0.318
Wu JX, Ding D, Wang M, Kang Y, Zeng X, Chen L
Protein Cell (2018) 9 pp. 553-567 [ Pubmed: 29594720 DOI: doi:10.1007/s13238-018-0530-y ]
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- Katp (Complex from Mus musculus)
Resolution: 4.33 Å
EM Method: Single-particle
Fitted PDBs: 5ykf
Q-score: 0.274
Wu JX, Ding D, Wang M, Kang Y, Zeng X, Chen L
Protein Cell (2018) 9 pp. 553-567 [ DOI: doi:10.1007/s13238-018-0530-y Pubmed: 29594720 ]
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- Katp (Complex from Mus musculus)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
Resolution: 4.57 Å
EM Method: Single-particle
Fitted PDBs: 5ykg
Q-score: 0.226
Wu JX, Ding D, Wang M, Kang Y, Zeng X, Chen L
Protein Cell (2018) 9 pp. 553-567 [ DOI: doi:10.1007/s13238-018-0530-y Pubmed: 29594720 ]
- 5-chloro-n-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide (494 Da, Ligand)
- Atp-sensitive inward rectifier potassium channel 11 (43 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family c member 8 isoform x2 (177 kDa, Protein from Mesocricetus auratus)
- Katp (Complex from Mus musculus)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)