Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C)"

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EMD-22336

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Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody

Release date: July 21, 2021
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 7jhg
Q-score: 0.345

Yan Y, Mukherjee S, Harikumar KG, Strutzenberg TS, Zhou XE, Suino-Powell K, Xu TH, Sheldon RD, Lamp J, Brunzelle JS, Radziwon K, Ellis A, Novick SJ, Vega IE, Jones RG, Miller LJ, Xu HE, Griffin PR, Kossiakoff AA, Melcher K

Science (2021) 373 pp. 413-419 [ DOI: doi:10.1126/science.abe7565 Pubmed: 34437114 ]

Sample:

5'-amp-activated protein kinase subunit beta-2 (22 kDa, Protein from Homo sapiens)
Fab light chain (23 kDa, Protein from synthetic construct)
Adenosine monophosphate (347 Da, Ligand)
Atp-bound fully inactive ampk in complex with dorsomorphin (compound c) (Complex from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)
Fab heavy chain (25 kDa, Protein from synthetic construct)
Fab-nanobody (Complex from synthetic construct)
Nanobody (17 kDa, Protein from synthetic construct)
Cryo-em structure of atp-bound fully inactive ampk in complex with dorsomorphin (compound c) and fab-nanobody (220 kDa, Complex)
5'-amp-activated protein kinase subunit gamma-1 (34 kDa, Protein from Homo sapiens)
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine (399 Da, Ligand)
Adenosine-5'-diphosphate (427 Da, Ligand)
5'-amp-activated protein kinase catalytic subunit alpha-1 (56 kDa, Protein from Homo sapiens)
Maltodextrin-binding protein (40 kDa, Protein from Escherichia coli K-12)

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