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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"BAP1/ASXL1 bound to the H2AK119Ub Nucleosome" AND author_orcid:"0000-0003-1944-3912" AND author_orcid:"0000-0001-6911-395x" AND author_orcid:"0000-0003-0982-8122" AND assembly_molecular_weight:{500000 TO 1000000] AND author_name:"Ezell RJ"

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EMD-40789

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BAP1/ASXL1 bound to the H2AK119Ub Nucleosome

Release date: Aug. 30, 2023
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8svf
Q-score: 0.383

Thomas JF, Valencia-Sanchez MI, Tamburri S, Gloor SL, Rustichelli S, Godinez-Lopez V, De Ioannes P, Lee R, Abini-Agbomson S, Gretarsson K, Burg JM, Hickman AR, Sun L, Gopinath S, Taylor HF, Sun ZW, Ezell RJ, Vaidya A, Meiners MJ, Cheek MA, Rice WJ, Svetlov V, Nudler E, Lu C, Keogh MC, Pasini D, Armache KJ

Sci Adv (2023) 9 pp. eadg9832-eadg9832 [ Pubmed: 37556531 DOI: doi:10.1126/sciadv.adg9832 ]

Sample:

Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
Dna/rna (327-mer) (102 kDa, Macromolecule from synthetic construct)
Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
Ubiquitin carboxyl-terminal hydrolase bap1 (80 kDa, Protein from Homo sapiens)
Histone h3.2 (15 kDa, Protein from Xenopus laevis)
Ubiquitin (8 kDa, Protein from Homo sapiens)
Histone h4 (11 kDa, Protein from Xenopus laevis)
Bap1/asxl1 bound to the h2ak119ub nucleosome (Complex from Homo sapiens)
Polycomb group protein asxl1 (165 kDa, Protein from Homo sapiens)
Dna/rna (187-mer) (58 kDa, Macromolecule from synthetic construct)

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