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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Cactin"

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EMD-16452

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Human spliceosomal PM5 C* complex

Release date: July 12, 2023
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8c6j
Q-score: 0.353

Dybkov O, Preussner M, El Ayoubi L, Feng VY, Harnisch C, Merz K, Leupold P, Yudichev P, Agafonov DE, Will CL, Girard C, Dienemann C, Urlaub H, Kastner B, Heyd F, Luehrmann R

Sci Adv (2023) 9 pp. eadf1785- [ DOI: doi:10.1126/sciadv.adf1785 Pubmed: 36867703 ]

Sample:

Peptidyl-prolyl cis-trans isomerase-like 3 (18 kDa, Protein from human)
U5 snrna (36 kDa, RNA from human)
Crooked neck-like protein 1 (83 kDa, Protein from human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
Rna-binding protein 8a (19 kDa, Protein from human)
Pre-mrna-splicing factor isy1 homolog (33 kDa, Protein from human)
Pre-mrna-processing factor 17 (65 kDa, Protein from human)
Guanosine-5'-triphosphate (523 Da, Ligand)
Intron-binding protein aquarius (171 kDa, Protein from human)
Pre-mrna-processing factor 19 (55 kDa, Protein from human)
Protein mago nashi homolog (17 kDa, Protein from human)
Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
Inositol hexakisphosphate (660 Da, Ligand)
U6 snrna (34 kDa, RNA from human)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from human)
Nitric oxide synthase-interacting protein (33 kDa, Protein from human)
Pm5 5' exon (78 kDa, RNA from Homo sapiens)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
Pleiotropic regulator 1 (57 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
U2 snrna (60 kDa, RNA from human)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
Potassium ion (39 Da, Ligand)
Pre-mrna-splicing factor cwc22 homolog (57 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
Splicing factor cactin (88 kDa, Protein from human)
Splicing regulator sde2 (49 kDa, Protein from human)
Pre-mrna-splicing factor slu7 (68 kDa, Protein from human)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
Cell division cycle 5-like protein (92 kDa, Protein from human)
Prkr-interacting protein 1 (21 kDa, Protein from human)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
Human spliceosomal c* complex assembled on pm5 pre-mrna (Complex from Homo sapiens)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
Sting er exit protein (25 kDa, Protein from human)
Protein fam32a (13 kDa, Protein from human)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
Probable atp-dependent rna helicase ddx41 (69 kDa, Protein from human)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
Snw domain-containing protein 1 (61 kDa, Protein from human)
Protein bud31 homolog (17 kDa, Protein from human)
Nf-kappa-b-activating protein (47 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
Splicing factor c9orf78 (33 kDa, Protein from human)
Protein fam50a (40 kDa, Protein from human)
Pm5 intron (74 kDa, RNA from Homo sapiens)
Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
Splicing factor ess-2 homolog (52 kDa, Protein from human)

[Show more]

EMD-32319

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The cryo-EM structure of human pre-C*-II complex

Release date: June 22, 2022
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7w5a
Q-score: 0.269

Zhan X, Lu Y, Zhang X, Yan C, Shi Y

Mol Cell (2022) 82 pp. 2769-2778.e4 [ DOI: doi:10.1016/j.molcel.2022.05.021 Pubmed: 35705093 ]

Sample:

U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
Pre-mrna-splicing factor slu7 (68 kDa, Protein from human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
Cactin (88 kDa, Protein from human)
Pre-mrna-processing factor 17 (65 kDa, Protein from human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
Cell division cycle 5-like protein (92 kDa, Protein from human)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
Pre-mrna (55 kDa, RNA from unidentified adenovirus)
Human pre-c*-ii complex (Complex from Homo sapiens)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
Inositol hexakisphosphate (660 Da, Ligand)
Guanosine-5'-triphosphate (523 Da, Ligand)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
Crooked neck-like protein 1 (100 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
Psme3-interacting protein (28 kDa, Protein from human)
Protein mago nashi homolog (17 kDa, Protein from human)
Rna-binding protein 8a (19 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
Pre-mrna-processing factor 19 (55 kDa, Protein from human)
Snw domain-containing protein 1 (61 kDa, Protein from human)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
Rna helicase aquarius (171 kDa, Protein from human)
Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
U5 snrna (37 kDa, RNA from human)
U6 snrna (34 kDa, RNA from human)
Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
U2 snrna (60 kDa, RNA from human)
Zinc ion (65 Da, Ligand)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
Pleiotropic regulator 1 (57 kDa, Protein from human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
Prkr-interacting protein 1 (21 kDa, Protein from human)
Pre-mrna (14 kDa, RNA from unidentified adenovirus)
Protein bud31 homolog (17 kDa, Protein from human)
Protein fam32a (13 kDa, Protein from human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
Protein casc3 (76 kDa, Protein from human)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)

[Show more]

EMD-32321

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The cryo-EM structure of human C* complex

Release date: June 22, 2022
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7w5b
Q-score: 0.192

Zhan X, Lu Y, Zhang X, Yan C, Shi Y

Mol Cell (2022) 82 pp. 2769-2778.e4 [ DOI: doi:10.1016/j.molcel.2022.05.021 Pubmed: 35705093 ]

Sample:

Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from human)
Pre-mrna (14 kDa, RNA from unidentified adenovirus)
Crooked neck-like protein 1 (100 kDa, Protein from human)
Cactin (88 kDa, Protein from human)
Small nuclear ribonucleoprotein g (8 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from human)
Rna-binding protein 8a (19 kDa, Protein from human)
Pre-mrna-processing factor 17 (65 kDa, Protein from human)
Guanosine-5'-triphosphate (523 Da, Ligand)
Pre-mrna-processing factor 19 (55 kDa, Protein from human)
Protein mago nashi homolog (17 kDa, Protein from human)
Small nuclear ribonucleoprotein f (9 kDa, Protein from human)
Inositol hexakisphosphate (660 Da, Ligand)
U5 small nuclear ribonucleoprotein 200 kda helicase (244 kDa, Protein from human)
Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from human)
Pleiotropic regulator 1 (57 kDa, Protein from human)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from human)
U2 snrna (60 kDa, RNA from human)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from human)
U6 snrna (34 kDa, RNA from human)
Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from human)
Zinc ion (65 Da, Ligand)
Protein casc3 (76 kDa, Protein from human)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from human)
Pre-mrna-splicing factor slu7 (68 kDa, Protein from human)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from human)
Cell division cycle 5-like protein (92 kDa, Protein from human)
Rna helicase aquarius (171 kDa, Protein from human)
Prkr-interacting protein 1 (21 kDa, Protein from human)
U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from human)
Adenosine-5'-triphosphate (507 Da, Ligand)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from human)
Protein fam32a (13 kDa, Protein from human)
Pre-mrna-splicing factor rbm22 (46 kDa, Protein from human)
Magnesium ion (24 Da, Ligand)
U5 small nuclear ribonucleoprotein 40 kda protein (39 kDa, Protein from human)
Small nuclear ribonucleoprotein e (10 kDa, Protein from human)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from human)
116 kda u5 small nuclear ribonucleoprotein component (109 kDa, Protein from human)
Snw domain-containing protein 1 (61 kDa, Protein from human)
Protein bud31 homolog (17 kDa, Protein from human)
Nf-kappa-b-activating protein (47 kDa, Protein from human)
Human pre-c*-i complex (Complex from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase e (33 kDa, Protein from human)
U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from human)
Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from human)
Eukaryotic initiation factor 4a-iii (46 kDa, Protein from human)
Pre-mrna-splicing factor syf2 (28 kDa, Protein from human)
Serine/arginine repetitive matrix protein 2 (300 kDa, Protein from human)
Pre-mrna (55 kDa, RNA from unidentified adenovirus)
U5 snrna (37 kDa, RNA from human)

[Show more]

EMD-4525

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Human post-catalytic spliceosome (P complex) stalled with DHX8 K594A mutant, overall map

Release date: Feb. 20, 2019
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6qdv
Q-score: 0.278

Fica SM, Oubridge C, Wilkinson ME, Newman AJ, Nagai K

Science (2019) 363 pp. 710-714 [ Pubmed: 30705154 DOI: doi:10.1126/science.aaw5569 ]

Sample:

Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
Peptidyl-prolyl cis-trans isomerase-like 1 (18 kDa, Protein from Homo sapiens)
Atp-dependent rna helicase dhx8 (Complex from Homo sapiens)
Pre-mrna-splicing factor cwc22 homolog (105 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor syf1 (100 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein e (9 kDa, Protein from Homo sapiens)
Protein fam32a (7 kDa, Protein from Homo sapiens)
Ligated exons: minx mrna (4 kDa, RNA from Human adenovirus 2)
Snw domain-containing protein 1 (33 kDa, Protein from Homo sapiens)
Pre-mrna-splicing factor spf27 (26 kDa, Protein from Homo sapiens)
Guanosine-5'-triphosphate (523 Da, Ligand)
Intron lariat: minx rna (27 kDa, RNA from Human adenovirus 2)
Pre-mrna-processing factor 17 (59 kDa, Protein from Homo sapiens)
Pleiotropic regulator 1 (35 kDa, Protein from Homo sapiens)
Inositol hexakisphosphate (660 Da, Ligand)
Pre-mrna-processing factor 19 (55 kDa, Protein from Homo sapiens)
Replication stress response regulator sde2 (4 kDa, Protein from Homo sapiens)
Atp-dependent rna helicase dhx8 (139 kDa, Protein from Homo sapiens)
Serine/arginine repetitive matrix protein 2 (2 kDa, Protein from Homo sapiens)
Potassium ion (39 Da, Ligand)
Pre-mrna-splicing factor slu7 (68 kDa, Protein from Homo sapiens)
116 kda u5 small nuclear ribonucleoprotein component (101 kDa, Protein from Homo sapiens)
Crooked neck-like protein 1 (100 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein-associated proteins b and b' (9 kDa, Protein from Homo sapiens)
U6 snrna (34 kDa, RNA from Homo sapiens)
Pre-mrna-splicing factor syf2 (17 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
Pre-mrna-splicing factor rbm22 (33 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)
Prkr-interacting protein 1 (14 kDa, Protein from Homo sapiens)
Cell division cycle 5-like protein (92 kDa, Protein from Homo sapiens)
Eukaryotic initiation factor 4a-iii (44 kDa, Protein from Homo sapiens)
Cactin (15 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d3 (9 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
U2 snrna (60 kDa, RNA from Homo sapiens)
Human post-catalytic p complex spliceosome (Complex from Homo sapiens)
Intron-binding protein aquarius (171 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 40 kda protein (34 kDa, Protein from Homo sapiens)
U2 small nuclear ribonucleoprotein b'' (10 kDa, Protein from Homo sapiens)
Nf-kappa-b-activating protein (3 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein f (8 kDa, Protein from Homo sapiens)
Pre-mrna-processing-splicing factor 8 (273 kDa, Protein from Homo sapiens)
U5 small nuclear ribonucleoprotein 200 kda helicase (197 kDa, Protein from Homo sapiens)
Small nuclear ribonucleoprotein sm d1 (9 kDa, Protein from Homo sapiens)
Spliceosome-associated protein cwc15 homolog (26 kDa, Protein from Homo sapiens)
U5 snrna (36 kDa, RNA from Homo sapiens)
Human post-catalytic p complex spliceosome (3 MDa, Complex)
Rna-binding protein 8a (10 kDa, Protein from Homo sapiens)
Protein bud31 homolog (17 kDa, Protein from Homo sapiens)
Minx introns and exons (Complex from Human adenovirus 2)
U2 small nuclear ribonucleoprotein a' (18 kDa, Protein from Homo sapiens)
Protein mago nashi homolog 2 (16 kDa, Protein from Homo sapiens)

[Show more]

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EMDB [4]

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