Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobody SbC4
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8rml
Q-score: 0.347
Drozdzyk K, Peter M, Dutzler R
eLife (2024) 13 [ DOI: doi:10.7554/eLife.96138 Pubmed: 38896440 ]
- Calcium homeostasis modulator protein 4 (35 kDa, Protein from Homo sapiens)
- Complex of heteromeric calhm2/4 channel with synthetic nanobody sbc4 (430 kDa, Complex from Homo sapiens)
- Synthetic nanobody sbc4 (12 kDa, Protein from synthetic construct)
- Calcium homeostasis modulator protein 2 (37 kDa, Protein from Homo sapiens)
Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8rmm
Q-score: 0.362
Drozdzyk K, Peter M, Dutzler R
eLife (2024) 13 [ DOI: doi:10.7554/eLife.96138 Pubmed: 38896440 ]
- Calcium homeostasis modulator protein 4 (35 kDa, Protein from Homo sapiens)
- Synthetic nanobody sbc2 (14 kDa, Protein from synthetic construct)
- Complex of heteromeric calhm2/4 channel with synthetic nanobody sbc4 (541 kDa, Complex from Homo sapiens)
- Calcium homeostasis modulator protein 2 (37 kDa, Protein from Homo sapiens)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
- Synthetic nanobody sbc4 (12 kDa, Protein from synthetic construct)
Cryo-EM structure of a dimer of decameric human CALHM4 in complex with synthetic nanobody SbC4
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8rmn
Q-score: 0.362
Drozdzyk K, Peter M, Dutzler R
eLife (2024) 13 [ DOI: doi:10.7554/eLife.96138 Pubmed: 38896440 ]
- Calcium homeostasis modulator protein 4 (35 kDa, Protein from Homo sapiens)
- Synthetic nanobody sbc4 (15 kDa, Protein from synthetic construct)
- Complex of calhm4 channel with synthetic nanobody sbc4 (1 MDa, Complex from Homo sapiens)
Cryo-EM structure of a dimer of decameric human CALHM4 in the absence of Ca2+
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 6ytk
Q-score: 0.434
Drozdzyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R
eLife (2020) 9 [ Pubmed: 32374262 DOI: doi:10.7554/eLife.55853 ]
- Calcium homeostasis modulator protein 4 (35 kDa, Protein from Homo sapiens)
- Dimer of decameric calhm4 (Complex from Homo sapiens)
Cryo-EM structure of a dimer of undecameric human CALHM4 in the absence of Ca2+
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 6ytl
Q-score: 0.456
Drozdzyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R
eLife (2020) 9 [ Pubmed: 32374262 DOI: doi:10.7554/eLife.55853 ]
- Calcium homeostasis modulator protein 4 (35 kDa, Protein from Homo sapiens)
- Dimer of undecameric calhm4 (Complex from Homo sapiens)
Cryo-EM structure of a dimer of decameric human CALHM4 in the presence of Ca2+
Resolution: 4.24 Å
EM Method: Single-particle
Fitted PDBs: 6yto
Q-score: 0.401
Drozdzyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R
eLife (2020) 9 [ DOI: doi:10.7554/eLife.55853 Pubmed: 32374262 ]
- Calcium homeostasis modulator protein 4 (35 kDa, Protein from Homo sapiens)
- Dimer of decameric calhm4 (Complex from Homo sapiens)
Cryo-EM structure of a dimer of undecameric human CALHM4 in the presence of Ca2+
Resolution: 4.02 Å
EM Method: Single-particle
Fitted PDBs: 6ytq
Q-score: 0.423
Drozdzyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R
eLife (2020) 9 [ Pubmed: 32374262 DOI: doi:10.7554/eLife.55853 ]
- Calcium homeostasis modulator protein 4 (35 kDa, Protein from Homo sapiens)
- Dimer of undecameric calhm4 (Complex from Homo sapiens)