Cryo-EM map of the human CTF18-RFC-PCNA binary complex in the three-subunit binding state (state 2)
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8umt
Q-score: 0.357
He Q, Wang F, O'Donnell ME, Li H
PNAS (2024) 121 pp. e2319727121-e2319727121 [ Pubmed: 38669181 DOI: doi:10.1073/pnas.2319727121 ]
- The human clamp-clamp loader complex pcna-ctf18 (300 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Chromosome transmission fidelity protein 18 homolog (107 kDa, Protein from Homo sapiens)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Cryo-EM map of the human CTF18-RFC-PCNA binary complex in the four-subunit binding state (state 3)
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 8umu
Q-score: 0.382
He Q, Wang F, O'Donnell ME, Li H
PNAS (2024) 121 pp. e2319727121-e2319727121 [ Pubmed: 38669181 DOI: doi:10.1073/pnas.2319727121 ]
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
- The human clamp-clamp loader complex pcna-ctf18 (300 kDa, Complex from Homo sapiens)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Chromosome transmission fidelity protein 18 homolog (108 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8umv
Q-score: 0.533
He Q, Wang F, O'Donnell ME, Li H
PNAS (2024) 121 pp. e2319727121-e2319727121 [ DOI: doi:10.1073/pnas.2319727121 Pubmed: 38669181 ]
- Dna (40-mer) (12 kDa, DNA from synthetic construct)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Dna (20-mer) (6 kDa, DNA from synthetic construct)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Chromosome transmission fidelity protein 18 homolog (107 kDa, Protein from Homo sapiens)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- The human clamp-clamp loader complex pcna-ctf18 (300 kDa, Complex from Homo sapiens)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8umw
Q-score: 0.495
He Q, Wang F, O'Donnell ME, Li H
PNAS (2024) 121 pp. e2319727121-e2319727121 [ DOI: doi:10.1073/pnas.2319727121 Pubmed: 38669181 ]
- Dna (40-mer) (12 kDa, DNA from synthetic construct)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Dna (20-mer) (6 kDa, DNA from synthetic construct)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Chromosome transmission fidelity protein 18 homolog (107 kDa, Protein from Homo sapiens)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- The human clamp-clamp loader complex pcna-ctf18 (300 kDa, Complex from Homo sapiens)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8umy
Q-score: 0.51
He Q, Wang F, O'Donnell ME, Li H
PNAS (2024) 121 pp. e2319727121-e2319727121 [ DOI: doi:10.1073/pnas.2319727121 Pubmed: 38669181 ]
- Dna (40-mer) (12 kDa, DNA from synthetic construct)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Dna (20-mer) (6 kDa, DNA from synthetic construct)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Chromosome transmission fidelity protein 18 homolog (107 kDa, Protein from Homo sapiens)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- The human clamp-clamp loader complex pcna-ctf18 (300 kDa, Complex from Homo sapiens)
Cryo-EM map of the human CTF18-RFC-PCNA-DNA ternary complex with cracked and closed PCNA (state 7)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8un0
Q-score: 0.451
He Q, Wang F, O'Donnell ME, Li H
PNAS (2024) 121 pp. e2319727121-e2319727121 [ Pubmed: 38669181 DOI: doi:10.1073/pnas.2319727121 ]
- Dna (40-mer) (12 kDa, DNA from synthetic construct)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- The human clamp-clamp loader complex pcna-ctf18 (300 kDa, Complex from Homo sapiens)
- Chromosome transmission fidelity protein 18 homolog (107 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Dna (20-mer) (6 kDa, DNA from synthetic construct)
Cryo-EM map of the human CTF18-RFC alone in the apo state (State 1)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8unj
Q-score: 0.288
He Q, Wang F, O'Donnell ME, Li H
PNAS (2024) 121 pp. e2319727121-e2319727121 [ DOI: doi:10.1073/pnas.2319727121 Pubmed: 38669181 ]
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- The human clamp loader ctf18_rfc (300 kDa, Complex from Homo sapiens)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Chromosome transmission fidelity protein 18 homolog (107 kDa, Protein from Homo sapiens)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6s2e
Q-score: 0.301
Stokes K, Winczura A, Song B, Piccoli G, Grabarczyk DB
Nucleic Acids Res (2020) 48 pp. 8128-8145 [ Pubmed: 32585006 DOI: doi:10.1093/nar/gkaa541 ]
- Chromosome transmission fidelity protein 8 (15 kDa, Protein from Saccharomyces cerevisiae S288C)
- Complex of the catalytic domain of dna polymerase epsilon with the ctf18-1-8 module of ctf18-rfc (200 kDa, Complex from Saccharomyces cerevisiae S288C)
- Chromosome transmission fidelity protein 18 (3 kDa, Protein from Saccharomyces cerevisiae S288C)
- Iron/sulfur cluster (351 Da, Ligand)
- Sister chromatid cohesion protein dcc1 (44 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna polymerase epsilon catalytic subunit a (139 kDa, Protein from Saccharomyces cerevisiae S288C)
Resolution: 5.8 Å
EM Method: Single-particle
Fitted PDBs: 6s2f
Q-score: 0.173
Stokes K, Winczura A, Song B, Piccoli G, Grabarczyk DB
Nucleic Acids Res (2020) 48 pp. 8128-8145 [ Pubmed: 32585006 DOI: doi:10.1093/nar/gkaa541 ]
- Iron/sulfur cluster (351 Da, Ligand)
- Chromosome transmission fidelity protein 8 (15 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Sister chromatid cohesion protein dcc1 (44 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna polymerase epsilon catalytic subunit a (140 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Complex of the catalytic domain of dna polymerase epsilon with the ctf18-1-8 module of ctf18-rfc (200 kDa, Complex from Saccharomyces cerevisiae S288C)
- Chromosome transmission fidelity protein 18 (3 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))